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-ADRENOCEPTOR: 作品数：52被引量：166H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：韩启德朱卫忠夏霖张幼怡涂植光更多>>; 相关机构：北京医科大学第三医院中国药科大学重庆医科大学华中科技大学更多>>; 相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Discovery of an enantiopure N-[2-hydroxy-3-phenyl piperazine propyl]-aromatic carboxamide derivative as highly selectiveα_(1D/1A)-adrenoceptor antagonist and homology modelling: 《Chinese Chemical Letters》2024年第11期435-441,共7页Junjun Huang Ran Chen Yajian Huang Hang Zhang Anran Zheng Qing Xiao Dan Wu Ruxia Duan Zhi Zhou Fei He Wei Yi; supported by Natural Science Foundation of Guangdong Province(Nos.2021A1515010101,2021A1515011372,2023A1515011895);National Natural Science Foundation of China(Nos.21807017,82273759,32371529);Guangzhou Medical University Scientific Research Capacity Improvement Project(No.02-410-2405104)。; α_(1)-Adrenergic receptor(AR)blockers can be effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms(BPH/LUTS),their usage is limited by cardiovascular-related side effects that are c...; 关键词：Benign prostatic hyperplasia α_(1)-AR antagonist Phenylpiperazine Homology modelling Subtype selectivity

Macrophage polarization is involved in liver fibrosis induced byβ_(1)-adrenoceptor autoantibody被引量：2: 《Acta Biochimica et Biophysica Sinica》2022年第8期1100-1112,共13页Ye Wu Xiongxiong Fan Haicun Yu Jingyi Liu Yanru Duan Suli Zhang Li Yan Yunhui Du Huirong Liu; the grants from the National Natural Science Foundation of China(Nos.81970334 and 81770393 to H.L.)。; Accumulating evidence suggests that liver injury can be induced by the over-expression ofβ_(1)-adrenergic receptors(β_(1)-ARs).High titers of autoantibodies specific toβ_(1)-adrenergic receptors(β_(1)-AA)are detec...; 关键词：β_(1)-adrenergic receptor AUTOANTIBODY hepatic fibrosis MACROPHAGES

Onset Time Profiles for Syncope Associated with α1-Adrenoceptor Blockers in Males: Analysis of a Spontaneous Adverse Drug Event Database: 《Pharmacology & Pharmacy》2018年第12期515-526,共12页Katsuhiro Ohyama Masaya Furumoto Munetoshi Sugiura; Background: α1-Adrenoceptor blockers (α1Bs) are used for the treatment of benign prostatic hyperplasia and hypertension, but they are known to cause hypotension-related adverse events. The objective of the present s...; 关键词：Reporting Odds Ratio Adverse Drug Event Report DATABASE SYNCOPE Α1-ADRENOCEPTOR Blocker

Clonidine Inhibits Phenylephrine-Induced Contraction of Rat Thoracic Aortae by Competitive Antagonism of α1-Adrenoceptors Independent of α2-Adrenoceptor Stimulation: 《Pharmacology & Pharmacy》2017年第5期172-188,共17页Daisuke Chino Mai Naramatsu Keisuke Obara Yoshio Tanaka; Clonidine is a classically categorized α2-adrenoceptor (α2-AR) agonist that produces vascular contractions by stimulating arterial smooth muscle α2-ARs. However, clonidine inhibits α1-AR-mediated arterial contract...; 关键词：CLONIDINE α2-Adrenoceptor (α2-AR) Α1-ADRENOCEPTOR (α1-AR) RAT Aorta Relaxation

Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α1D-adrenoceptor antagonists: 《Acta Pharmaceutica Sinica B》2017年第4期496-501,共6页Wei Xu Junjun Huang Renwang Jiang Mu Yuan; supported by grants from the National Science Foundation of Guangdong Province (No. S2013040014088);the Postdoctoral Science Foundation of Guangzhou City (Q188);partially supported by the Guangdong Major Scientific and Technological Special Project for New Drug Development (2013A022100029); Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers s...; 关键词：NAFTOPIDIL Crystal structure α1D-Adrenoceptor antagonists Binding mode Pharmacophore model

Systematic review and meta-analysis on phosphodiesterase 5 inhibitors and α-adrenoceptor antagonists used alone or combined for treatment of LUTS due to BPH被引量：1: 《Asian Journal of Andrology》2015年第6期1022-1032,I0012,共12页Xing-Huan Wang Xiao Wang Ming-Jun Shi Sheng Li Tao Liu Xin-Hua Zhang; The aim of this systematic review is to determine the comparative effectiveness and safety of phosphodiesterase 5 inhibitors （PDE5-1s） and （x-blockers used alone or combined for the treatment of lower urinary tract...; 关键词：benign prostatic hyperplasia lower urinary tract symptoms META-ANALYSIS phosphodiesterase 5 inhibitors -adrenoceptorantagonists

Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenalineinduced vascular contraction in Wistar rats被引量：3: 《Journal of Integrative Medicine》2015年第3期194-200,共7页Kylie Connolly Douglas Jackson Candice Pullen Andrew Fenning; OBJECTIVE： Crassostrea gigas oyster extract has been reported to have antioxidant, antihypertensive and lipid-lowering properties that may be useful for treating cardiovascular diseases. This study aimed to evaluate ...; 关键词：CRASSOSTREA hypertension calcium channels receptors adrenergic rats

β_2-adrenoceptor in obstructive airway diseases:Agonism, antagonism or both?被引量：1: 《World Journal of Respirology》2015年第3期199-206,共8页Daniel WS Tan Jyi Lin Wong Siew Teck Tie John A Abisheganaden Albert YH Lim WS Fred Wong; Supported by NMRC/CBRG/0027/2012 from the National Medical Research Council of Singapore(in part);by NUHS Seed Fund R-184-000-238-112; Obstructive airway disease is a complex disease entity including several maladies characterized by bronchoconstriction and abnormal airway inflammation. Reversing bronchoconstriction leads to symptomatic relief and im...; 关键词：β-adrenoceptors β2-agonist Β-BLOCKER Inverse agonist Heart failure Β-ARRESTIN

Hypersensitivity of vascular alpha-adrenoceptor responsiveness: a possible inducer of pain in neuropathic states: 《Neural Regeneration Research》2015年第1期165-165,共1页Robert W.Teasell Qingping Feng; Dear editor,Dr. Peter Drummond＇s article noted that peripheral nerve and tissue injury in neuropathic pain syndromes releases cytokines which in turn lead to an increase in alphal-adrenoceptor upreg- ulation, resulti...; 关键词：Hypersensitivity of vascular alpha-adrenoceptor responsiveness a possible inducer of pain in neuropathic states

Selective α1B- and α1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro被引量：1: 《Acta Pharmacologica Sinica》2014年第11期1385-1392,共8页Ting-ting LIU Ti-long DING Yong MA Wei WEI; Acknowledgements This study was supported by the National Natural Science Foundation of China （No 81173075） and the Nanjing Military Medical Science and Technology Innovation Foundation of China （No 10MA037）.; Aim： To explore the effects of noradrenaline （NA） on hepatic stellate cells （HSCs） in vitro and to determine the adrenoceptor （AR） subtypes and underlying mechanisms. Methods： The distribution and expressions ...; 关键词：NORADRENALINE hepatic fibrosis hepatic stellate cell Α1-ADRENOCEPTOR G. PKC PI3K AKT

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