CD147在甲状旁腺癌中的表达及其临床意义  

Expression and clinical significance of CD147 in parathyroid carcinoma

作　　者：杜雪梅[1] 王玲玲[1] 昌红[1] 孟巍[1] 张建英[1] 沈兵[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院病理科,100038

出　　处：《中华病理学杂志》2016年第6期372-374,共3页Chinese Journal of Pathology

摘　　要：目的探讨CD147在甲状旁腺癌中的表达及其临床意义。方法收集2012--2015年14例甲状旁腺癌及33例甲状旁腺腺瘤病例，运用免疫组织化学EnVision法检测CD147在甲状旁腺癌和甲状旁腺腺瘤中的表达情况。结果CD147阳性显色为棕黄色，以胞膜着色为主，出现少量胞质着色。14例甲状旁腺癌，其中11例CD147阳性3＋，3例CD147阳性2＋；33例甲状旁腺腺瘤病例，其中8例CD147阳性2＋，15例阳性1＋，10例阴性。CD147在甲状旁腺癌组织中高表达，与在甲状旁腺腺瘤中的表达情况相比，差异具有统计学意义（P〈0．05）。结论免疫组织化学染色CD147在甲状旁腺癌组织中高表达可辅助诊断甲状旁腺癌。Objective To study the expression and clinical significance of CD147 in the patients of parathyroid carcinoma. Methods Fourteen cases of parathyroid carcinoma encountered during the period from 2012 to 2015 were enrolled. Thirty three cases of parathyroid adenoma encountered during the same period were enrolled. The expression of CD147 in parathyroid carcinoma and parathyroid adenoma was studied by means of immunohistochemistry （ EnVision method）. Results CD147 positive color was brown and yellow, and positive position was located mainly in the cytomembrane, and a small amount of cytoplasm was appeared. Among 14 cases of parathyroid carcinoma, 11 cases of CD147 positive score was 3 ＋ , 3 cases of CD147 positive score was 2 ＋ ; Among 33 cases of parathyroid adenoma , 8 cases of CD147 positive score was 2 ＋ , 15 cases of it was 1 ＋ , 10 cases of it was negative. CD147 was highly expressed in parathyroid carcinoma tissues, and the expression of CD147 was significantly different from the expression of parathyroid adenoma（P 〈0. 05 ）. Conclusion CD147 immunohistochemical staining can help to diagnose parathyroid carcinoma.

关 键 词：甲状旁腺肿瘤 免疫组织化学 诊断 鉴别 

分 类 号：R736.2[医药卫生—肿瘤]