降尿酸治疗对无症状性高尿酸血症脑梗死疗效观察  

Clinical Observation of Allopurinol in Cerebral Infarction Patients with Asymptomatic Hyperuricemia

作　　者：黄雄[1] 崔晓艳[1] 黄成锋[1] 

机构地区：[1]高州市人民医院,广东高州525200

出　　处：《深圳中西医结合杂志》2016年第9期23-25,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨对无症状性高尿酸血症脑梗死患者采取降尿酸治疗的疗效。方法:选取60例于2013年8月至2014年8月本院接收的脑梗死伴无症状性高尿酸血症患者,将其根据治疗方案分为对照组与观察组,对照组均给予常规治疗,观察组在此基础上加用别嘌醇治疗,观察两组疗效。结果:观察组应用别嘌醇后美国国立卫生院卒中量表(NIHSS)评分在治疗后2周、3个月、1年改善(P<0.05),1年后行临床疗效比较,观察组有效率高于对照组,组间比较,差异具有统计学意义(P<0.05);两组患者均未出现肝肾损伤,随访1年,观察组复发率显著低于对照组(P<0.05)。结论:无症状性高尿酸血症脑梗死采取别嘌醇治疗,可降低血清尿酸水平,降低神经功能缺损评分。Objective To explore the clinical efficacy of Allopurinol in cerebral infarction patients complicated with asymptomatic hyperuricemia. Method： 60 cerebral infarction patients complicated with asymptomatic hyperuricemia treated from August 2013 to August 2014 in our hospital were selected. The subjects were divided into two groups according to different therapies. The control group adopted the conventional therapy; on the basis, the observation group also took Allopurinol. The clinical efficacy for two groups was observed. Result： After 2w, 3m and 1y of treatment, the point of NIHSS for observation group was better than control group（P 〈0.05）; after 1y of treatment, the effective rate of observation group was higher than control group（P 〈0.05）; the effective rate for two groups was significantly different（P 〈0.05）; there were no cases of liver and renal injury;after 1y of treatment, the recurrence rate for observation group was lower than control group（P 〈0.05）.Conclusion： For cerebral infarction patients complicated with asymptomatic hyperuricemia, Allopurinol can reduce the level of serum uric acid as well as the point of NIHSS.

关 键 词：脑梗死 高尿酸血症 别嘌醇 神经功能缺损评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]