艾司西酞普兰治疗难治性焦虑症状的自身对照研究  

A Self-control Study of S-citalopram for Refractory Anxiety

作　　者：唐颖[1,2] 王丽萍[1,2] 田悦[1,2] 程奥博 

机构地区：[1]中国.华北理工大学附属开滦精神卫生中心,河北唐山 [2]华北理工大学精神卫生研究所

出　　处：《中国健康心理学杂志》2016年第6期806-808,共3页China Journal of Health Psychology

摘　　要：目的:探讨艾司西酞普兰治疗难治性焦虑症状的疗效和安全性。方法:选取30例应用其它抗抑郁药物治疗的广泛性焦虑症和抑郁症患者焦虑症状无明显改善者,全部换用艾司西酞普兰治疗8周。分别于换药前与换药后1、2、4、8周进行汉密尔顿焦虑量表(HAMA)评定其抗焦虑疗效,用药物治疗中需处理的副作用症状量表(TESS)评定治疗中出现的不良反应,同时进行血常规、心电图及肝、肾功能检查。结果:换药前与换药后的第1周末HAMA评分比较无显著差异性;换药前与换药后的第2、4、8周HAMA评分比较有显著差异性(t=13.53,9.48,8.71;P<0.05)。不良反应:换药前与换药后TESS评分比较差异无显著性(P>0.05)。心电图,血常规及肝、肾功能检查与换药前相比无明显变化。结论:艾司西酞普兰治疗难治性焦虑症状有明显改善且用药安全、不良反应轻微。Objective：To investigate the efficacy and safety of theatment of s -citalopram for intractable anxiety . Methods：A total of 30 patients with anxiety disorder or depression who were inefficacy treatment of else antidepres‐sant for anxiety .All patients who were changed to s-citalopram for 8 weeks treatment .The HAMA and TESS were evaluated at baseline and 1 ,2 ,4 ,8 week after changed .Results：Scores of HAMA after 1 week had no significant difference with baseline（P〉0 0.5）;Scores of HAMA after 2 week had significant difference with baseline（t=13 5.3 , 9 4.8 ,8 7.1 ;P〈0 0.5） S.cores of TESS had no significant difference between baseline and after（P〉0 0.5） .Blood rou‐tine examination ,electrocardiogram ,liver function test and renal function test after changed had no significant differ‐ence with baseline（P〉0 0.5） .Conclusion：S-citalopram has a effect on refractory anxiety symptoms with much med‐ication safety and fewer adversive reactions .

关 键 词：艾司西酞普兰 难治性焦虑症状 焦虑症 抑郁症 

分 类 号：R749.053[医药卫生—神经病学与精神病学]