乳腺癌的相衬成像  

Phase contrast imaging for breast cancer

作　　者：监悟帅[1] 沈富强[1] 孙郁[1] 徐伟华[1] 许涛[1] 张璐[2] 石宏理[2] 

机构地区：[1]廊坊市人民医院放射科,河北廊坊065000 [2]首都医科大学生物医学工程学院,北京100069

出　　处：《中国医学物理学杂志》2016年第6期584-587,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(81401549);河北省科技支撑项目(14277742D)

摘　　要：目的:应用相衬成像技术观察和分析良、恶性乳腺肿瘤的区别。方法:使用上海光源同步辐射装置对人体乳腺肿瘤离体标本行相衬CT检查。共选取3例人体早期乳腺癌标本(早期浸润型导管癌)和3例乳腺腺瘤样本,对两组图像进行三维重建和比较,并采用灰度共生矩阵提取两组CT图像的纹理特征。结果:良、恶性肿瘤的CT图像有明显差别。三维重建结果清晰地显示肿瘤周围的脂肪组织和肿瘤内部散在的脂肪组织,可用于早期良、恶性肿瘤的鉴别诊断。图像纹理参数也显示两组图像间存在显著统计学差异(P<0.001)。结论:相衬成像能充分显示乳腺正常组织和病变组织的细节。Objective To observe and analyze the benign and malignant breast tumors by using phase contrast imaging （PCI）. Methods The synchronous radiation facility in Shanghai was used to perform PCI scan for the human breast specimens in vitro. Three early breast cancer specimens which were early infiltrating ductal carcinoma and three mammary gland adenomas were selected in the study. The three-dimensional reconstruction and comparison of the two groups of images were performed. The textural features were extracted by gray-level co-occurrence matrix. Results The CT images of benign and malignant tumors showed significant differences. The three-dimensional reconstruction results clearly showed the adipose tissues around the tumors and the adipose tissues inside the tumors, which were significant for the diagnosis of benign and malignant tumors. The texture features also proved the two groups of images had statistical differences （P〈0.001）. Conclusion PCI can offer the details of normal and diseased breast tissues.

关 键 词：相衬成像 乳腺癌 三维重建 图像纹理 

分 类 号：R737.9[医药卫生—肿瘤]