大蒜素体外抗猴甲型轮状病毒的研究  

Effect of garlicin on Simian rotavirus A in vitro

作　　者：王佳美[1] 王胜男[1] 陈江曼[1] 赵微[1] 李永刚[1] 

机构地区：[1]辽宁医学院基础医学院,辽宁锦州121000

出　　处：《中国现代医学杂志》2016年第11期1-6,共6页China Journal of Modern Medicine

基　　金：国家自然基金青年基金(No:81201285);辽宁省博士启动基金(No:20141134);辽宁医学院领军人物创新团队(No:173615007)

摘　　要：目的研究大蒜素体外抗猴甲型轮状病毒(SA11)的作用。方法通过病毒滴度测定来确定大蒜素能否抗SA11以及最佳浓度。结果大蒜素对MA104细胞的最大无毒浓度为100 mg/ml,病毒滴度测定可以得出,50 mg/ml的大蒜素可以抑制SA11感染的MA104细胞出现细胞病变效应(CPE)。结论一定浓度的大蒜素在体外有抗SA11的作用。Objective To investigate the effect of garlicin on Simian rotavirus A （SAll） in vitro. Methods Various concentrations of garlicin were used to inhibit SAIl replication so as to find out the best concentration for the inhibition. Results The maximal nontoxic concentration of garlicin for MA104 cells was 100 mg/ml. Tissue culture revealed that 50 mg/ml garliein could inhibit the cytopathic effect of MA104 cells infected by SAIl. Conclusions Garlicin could produce obvious inhibitory effects on Simian rotavirus A in vitro.

关 键 词：猴甲型轮状病毒 大蒜素 抗病毒 MA104细胞 

分 类 号：R373[医药卫生—病原生物学]