内镜下聚桂醇注射液硬化治疗食管静脉曲张破裂出血的效果观察  

Endoscopic injection of lauromacrogol sclerotherapy for esophageal variceal hemorrhage caused by rupture

作　　者：司淑平[1] 占强[1] 王辉[1] 许玉花[1] 

机构地区：[1]南京医科大学附属无锡市人民医院消化内科,江苏无锡214023

出　　处：《中国内镜杂志》2016年第6期1-4,共4页China Journal of Endoscopy

基　　金：无锡市科技发展资金(No:CSE31N1501)

摘　　要：目的探讨内镜下不同的硬化剂治疗食管静脉曲张破裂出血(EVB)的效果。方法肝硬化EVB的患者66例,随机分为药物治疗A组、内镜下聚桂醇硬化剂治疗B组和内镜下德国1%乙氧硬化醇硬化剂治疗C组,观察成功止血情况,静脉曲张疗效,以及随访患者出血、发热等不良情况的发生。结果 B组和C组患者止血成功率较A组有明显优势,差异有统计学意义(P<0.05);B组患者静脉曲张疗效总有效率明显高于A组患者,差异有统计学意义(P<0.05);B组在早期再出血、迟发性再出血方面较C组少,差异无统计学意义(P>0.05);B组发热、溃疡、疼痛情况较C组少,差异有统计学意义(P<0.05)。结论内镜下聚桂醇注射液硬化治疗EVB是一种安全、迅速、及时、有效且可重复的治疗方法,值得临床上大力推广应用。Objective To investigate the effect of different endoscopic sclerotherapy for esophageal variceal bleed- ing caused by rupture. Methods 66 cases of liver cirrhosis with esophageal variceal bleeding were randomly divided into treatment group A, endoscopic lauromacrogol sclerotherapy group B and endoscopic aethoxysklerol 1% German agents in treatment of group C, then observe the successful hemostasis, the curative effect and follow-up of patients with varices, bleeding, fever and other adverse conditions. Results Group B and group C with success rate of hemostasis has obvious advantages compared with group A, P 〈 0.05, the difference was statistically significant; total effective rate of group B was significantly higher than that in group A, P 〈 0.05, the difference was statistically sig- nificant; early period of rebleeding, delayed again bleeding in group B was occurred less than that of group C, P 〉 0.05, the difference was not statistically significant; adverse conditions such as fever, ulcers, pain in group B was less than that in group C, P 〈 0.05, the difference was statistically significant. Conclusion Endoscopic lauromacrogol injection sclerotherapy for esophageal varieeal bleeding is a safe, fast speed, timely, effective and repeatable treat- ment, it is worthy of promoting clinical application.

关 键 词：内镜下硬化剂治疗 聚桂醇 食管静脉曲张破裂出血 疗效 

分 类 号：R571.3[医药卫生—消化系统]