GPR30和VEGF蛋白在子宫内膜腺癌中的阳性表达率及临床价值  

Positive expression rates of GPR30 and VEGF proteins in endometrial adenocarcinoma and the clinical significance

作　　者：周云霞[1] 刘婵桢[1] 宋红林[1] 张洁清[1] 李力[1] 

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科,广西南宁530021

出　　处：《中国妇幼保健》2016年第12期2535-2538,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金项目(81160318);广西医疗卫生重点科研课题(重2012094);广西区域性高发肿瘤早期防治研究重点实验(GK2015-ZZ08)

摘　　要：目的探讨G蛋白偶联受体30(GPR30)及血管内皮生长因子(VEGF)蛋白在子宫内膜样腺癌组织中的阳性表达率及其与临床病理特征的关系,分析GPR30及VEGF蛋白在子宫内膜腺癌发生、发展中的作用。方法采用免疫组化SP法检测GPR30与VEGF蛋白在93例子宫内膜腺癌、37例不典型增生子宫内膜和31例正常子宫内膜组织中的阳性表达率。结果GPR30和VEGF蛋白在子宫内膜腺癌中的阳性表达率分别为65.59%和58.06%,均显著高于不典型增生子宫内膜及正常子宫内膜(P<0.05)。随临床分期升高及淋巴结转移,GPR30及VEGF蛋白在子宫内膜腺癌中的阳性表达率均明显升高,差异有统计学意义(P<0.05),但不同肌层浸润深度比较差异无统计学意义(P>0.05);随着组织学分级升高,GPR30蛋白阳性表达率明显升高,VEGF蛋白阳性表达率则无显著变化。GPR30与VEGF蛋白在子宫内膜腺癌组织中的阳性表达率呈正相关。结论GPR30及VEGF蛋白的阳性表达率与子宫内膜腺癌的发生、发展有关,GPR30及VEGF检测有助于评估子宫内膜腺癌的生物学行为和预后。Objective To explore the positive expression rates of G protein-coupled receptor 30 （GPR30） and vascular endothelial growth factor （VEGF） proteins in endometrial adenoearcinoma and the relationships with clinicopathological feathres, analyze the roles of GPR30 and VEGF in oncogenesis and development of endometrial adenocarcinoma. Methods Immunohistoehemical SP method was used to detect the expressions of GPR30 and VEGF in 93 cases with endometrial adenocarcinoma, 37 cases with atypical endometrial hyperplasia, and 31 cases with normal endometrium. Results The positive expression rates of GPR30 and VEGF in endometrial adenocarcinoma were 65.6% and 58. 1% , respectively, which were statistically significantly higher than those in atypical endometrial hyperplasia and normal en- dometrium （ P〈O. 05 ） . The positive expression rates of GPR30 and VEGF in endometrial adenocarcinoma increased significantly with the increase of clinical stages and lymph node metastasis （ P〈0. 05 ）, but there was no statistically significant difference among the cases with different depths of myometrial invasion （ P〉0. 05 ） ; the positive expression rate of GPR30 increased significantly with increase of histological grades, but the positive expression rate of VEGF didn＇t change significantly. The positive expression rate of GPR30 was positively correlated with positive expression rate of VEGF in endometrial adenoearcinoma （ P〈0. 05 ） . Conclusion The positive expression rates of GPR30 and VEGF are correlated with oncogenesis and development of endometrial adenocarcinoma, detection of GPR30 and VEGF can help to evaluate biological behavior and prognosis of endometrial adenoearcinoma.

关 键 词：子宫内膜腺癌 G蛋白偶联受体30 血管内皮生长因子 

分 类 号：R737.33[医药卫生—肿瘤]