内质网压力响应相关的蛋白质降解  

Protein Degradation Related to Endoplasmic Reticulum Stress

作　　者：闫孟节 侯运华[1] 吕珊珊[1,2] 钟耀华[2] 

机构地区：[1]齐鲁工业大学生物工程学院,济南250353 [2]山东大学生命科学学院微生物技术国家重点实验室,济南250100

出　　处：《生物化学与生物物理进展》2016年第6期539-549,共11页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(31370135);山东大学基本科研业务费专项资金(2015CJ005);山东省农业科技成果转化资金(2014-45)资助项目~~

摘　　要：内质网相关蛋白质降解途径(ERAD),即蛋白质分泌过程中错误折叠或未折叠的蛋白质在内质网中被识别并逆向运输到细胞质经聚泛素化后由蛋白酶体降解的过程.自从发现该途径后对其机制的阐明一直处于不断探索的阶段.近年来,对ERAD底物识别、逆向运输和泛素化新组分的发现以及新技术的应用,使得该途径的具体分子机制更加清晰.本文全面梳理并综述了内质网应激响应、ERAD降解过程与机理的最新进展,并对模式蛋白底物和最新研究方法进行了总结,以期展示该领域的研究概况.Endoplasmic reticulum associated degradation（ERAD） is a mechanism, which recognizes misfolded and unfolded proteins of the ER and retrotranslocates them into the cytoplasm for degradation by the ubiquitin-protesome machinery. Since it was discovered, many researches have conducted to contribute to understanding the mechanism of this conserved pathway. Recently, with the significant progresses in identification of new components revolved in substrate recognition, retrotranslocation and ubiquitylation, as well as the development of new techniques in this area, the specific molecular mechanism of ERAD becomes more clear. The recent progress in the ER stress response and the roles of the components related to ERAD process are summarized with focuses on their molecular mechanisms to provide an overview of this field. Also, the model ERAD substrates and the novel strategies recently developed are included.

关 键 词：内质网 分泌压力 错误折叠蛋白质 ERAD Hrd1 

分 类 号：Q256[生物学—细胞生物学]