云南高校图书馆联盟文献共享服务平台- ERAD

ERAD: 作品数：31被引量：62H指数：4; 导出分析报告; 相关领域：生物学医药卫生更多>>; 相关作者：王理槐谢旗刘华张险峰侯运华更多>>; 相关机构：中国科学院大学湖南中医药大学山东大学湖南中医药大学第一附属医院更多>>; 相关期刊：《社区医学杂志》《中国中医药现代远程教育》《Chinese Medical Journal》《医用放射技术杂志》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家科技部农业科技成果转化资金中央级公益性科研院所基本科研业务费专项更多>>

蛋白质二硫键异构酶与内质网相关降解关系的探究: 《工业微生物》2025年第1期237-239,共3页吴佳莲; 蛋白质二硫键异构酶(Protein disulfide isomerase,PDI)作为一类多功能氧化还原酶,参与蛋白质合成、折叠和修饰等多个过程。最新研究表明,酵母和哺乳动物体内的PDI与内质网甘露糖苷酶协同作用,参与一种特殊的内质网相关降解(Endoplasmic...; 关键词：PDI ERAD α1 2-甘露糖苷酶

外泌体中miR-181a-3p通过UPR/ERAD通路轴调控肺癌对安罗替尼的耐药性: 《实用癌症杂志》2024年第12期1921-1924,共4页朱凯陈胜佳张爱萍钟巧凤林金兰徐振武; 福建省肿瘤医院院内资助科研项目(编号:2021YN08)。; 目的探讨外泌体中miR-181a-3p通过未折叠蛋白反应(UPR)/内质网相关蛋白降解(ERAD)通路轴调控肺癌对安罗替尼的耐药性。方法选取人非小细胞肺癌细胞HCC827进行培养,并使用梯度浓度的安罗替尼持续处理诱导安罗替尼耐药性HCC827细胞(HCC827...; 关键词：外泌体 miR-181a-3p UPR/ERAD通路轴肺癌安罗替尼耐药性

ERAD: Enhanced Ransomware Attack Defense System for Healthcare Organizations: 《Journal of Software Engineering and Applications》2024年第5期270-296,共27页Xinyue Li Vijay K. Madisetti; Digital integration within healthcare systems exacerbates their vulnerability to sophisticated ransomware threats, leading to severe operational disruptions and data breaches. Current defenses are typically categorize...; 关键词：Ransomware Healthcare Cybersecurity MITRE ATT&CK Matrix Incident Response Ransomware Attack Lifecycle Digital Health Safety

Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells被引量：2: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第3期212-232,共21页Hong CAO Xuchang ZHOU Bowen XU Han HU Jianming GUO Yuwei MA Miao WANG Nan LI Jun ZOU; This work was supported by the National Natural Science Foundation of China(No.82071762);the Shanghai Key Lab of Human Performance(Shanghai University of Sport)(No.11DZ2261100);the 2021 Capacity Building of Shanghai Universities(No.21010503600),China。; The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulu...; 关键词：Endoplasmic reticulum-associated degradation(ERAD) Protein folding UBIQUITINATION Retrotranslocation

DGS1 improves rice disease resistance by elevating pathogenassociated molecular pattern-triggered immunity被引量：1: 《aBIOTECH》2024年第1期46-51,共6页Yu Wang Chuan Zheng You-liang Peng Qian Chen; supported by the National Natural Science Foundation of China (32072368);the 2115 Talent Development Program of China Agricultural University.; Rice yield and disease resistance are two crucial factors in determining the suitability of a gene for agricultural breeding.Decreased grain size1(DGS1),encoding an RING-type E3 ligase,has been found to have a positiv...; 关键词：Rice blast PTI ERAD E2-E3 pair UBIQUITINATION

基于ERAD-ERSIA稳态探讨健脾益肾法干预癌症恶病质骨骼肌萎缩: 《湖南中医药大学学报》2023年第12期2305-2312,共8页王理槐孙银辉陈晟刘正艺胡宇翔万多田雪飞; 湖南省自然科学基金项目(2021JJ30525);湖南中医药大学一流学科开放基金项目(2019ZXYJH03);湖南省科学技术厅湖南省中医肿瘤临床研究中心平台项目(2021SK4023)。; 癌症恶病质(cancer cachexia,CC)是癌症中晚期常见的致死并发症。现代医学营养支持只能在一定程度上缓解CC,总体疗效欠佳。CC属于中医学“虚劳”范畴,脾肾亏虚为主要病机。健脾益肾法能有效干预CC,但其具体机制尚未完全阐明。内质网应激...; 关键词：癌症恶病质内质网应激内质网应激相关性降解骨骼肌萎缩健脾益肾

基于miRNA介导的ERAD-ERSIA稳态失衡探讨肺癌恶病质正虚伏毒病机: 《湖南中医药大学学报》2023年第11期2018-2023,共6页王理槐孙银辉陈晟刘正艺胡宇翔刘华; 湖南省自然科学基金项目(2021JJ30525,2023JJ40486);湖南省科学技术厅湖南省中医肿瘤临床医学研究中心项目(2021SK4023)。; 肺癌恶病质(lung cancer cachexia,LCC)是肺癌中晚期的常见并发症。现代医学营养支持仅在一定程度上缓解LCC,总体疗效欠佳。恶病质属于中医学“虚劳”范畴,继发于肺癌的LCC又有其特有的病机特点。正虚伏毒是LCC的重要病机,探索并丰富该...; 关键词：肺癌恶病质内质网应激内质网应激相关性降解骨骼肌萎缩正虚伏毒

扶正口服液对诱导性癌症恶病质裸鼠骨骼肌中ERAD/ERSIA通路的影响被引量：4: 《湖南中医药大学学报》2022年第11期1816-1822,共7页孙银辉何晓李涵宇窦娴陈晟彭慧婷杨晓刘华李菁王理槐; 湖南省中医肿瘤临床研究中心平台项目(2021SK4023);湖南省自然科学基金项目(2021JJ30525);湖南省教育厅优秀青年项目(19B419);湖南省中医药科研计划项目(2021214);湖南省卫生健康委员会科研计划项目(C2019092)。; 目的探究扶正口服液对癌症恶病质(cancer cachexia,CC)裸鼠骨骼肌内质网应激相关性降解(ER-associated degradation,ERAD)/内质网应激性凋亡(endoplasmic reticulum stress induced apoptosis,ERSIA)信号通路的影响。方法选取36只6~7周...; 关键词：癌症恶病质扶正口服液 ERAD/ERSIA通路裸鼠骨骼肌

Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis: 《Journal of Genetics and Genomics》2022年第3期195-207,共13页Fuli Liu Hang Zhao Ruiyan Kong Lin Shi Zhengran Li Rui Ma Huiqing Zhao Zhouhua Li; supported by grants from the National Natural Science Foundation of China (31972893, 92054109 and 31471384);Beijing Municipal Commission of Education (No KZ201910028040);Beijing Natural Science Fundation (No 5162004)。; Adult stem cells are critical for the maintenance of residential tissue homeostasis and functions. However,the roles of cellular protein homeostasis maintenance in stem cell proliferation and tissue homeostasis are no...; 关键词：Derlin-1 TER94/VCP/p97 ERAD Intestinal homeostasis DROSOPHILA

Endoplasmic reticulum-related E3 ubiquitin ligases: Key regulators of plant growth and stress responses被引量：1: 《Plant Communications》2021年第3期1-10,共10页Ruijun Liu Ran Xia Qi Xie Yaorong Wu; supported by National Natural Science Foundation of China grant 31972862;by Transgenic Research Project(2018ZX08009-11B-002).; Accumulating evidence has revealed that the ubiquitin proteasome system plays fundamental roles in the regulation of diverse cellular activities in eukaryotes.The ubiquitin protein ligases(E3s)are central to the prote...; 关键词：E3 ligase plant endoplasmic reticulum UPS ERAD stress response

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