表皮生长因子受体蛋白在胃癌组织中的表达及其临床意义  

The Association between EGFR Expression in the Gastric Cancer and Clinical Pathology Characteristics

作　　者：徐丽艳[1] 杨金镇 葛玲[1] 陈艳[1] 周智俊[1] 杨清云[1] 郑凤春[1] 柳淑静 陈奋发 

机构地区：[1]福建省厦门市第三医院病理科,361100

出　　处：《医学理论与实践》2016年第11期1415-1417,共3页The Journal of Medical Theory and Practice

摘　　要：目的：探讨表皮生长因子受体（EGFR）在人胃癌组织中的表达及其临床意义。方法：对2011年2月-2015年10月我院普外科收治并手术治疗的52例胃癌患者的临床资料及组织病理学标本进行回顾性分析。采用免疫组织化学SP法检测52例胃癌患者癌组织及其中28例远癌正常胃组织中EGFR蛋白的表达水平,并分析其表达与患者临床病理学特征及预后的关系。结果：胃癌组织中EGFR与远癌正常胃组织中阳性表达率分别为46.2%和21.4%,癌组织阳性率显著高于正常胃组织（P〈0.05）;临床病理特征分析显示癌组织中EGFR阳性表达与患者肿瘤的大小、浸润深度和淋巴结转移有关（P〈0.05）;EGFR阳性患者的中位生存时间为17.2个月,显著低于阴性患者25.4个月（HR=2.01,95%CI：1.22~3.84,P〈0.05）。结论：EGFR蛋白在人胃癌各级组织中表达率较高,阳性与胃癌患者的预后不良有关。Objective：To discuss the EGFR expression in the gastric cancer tissue and association with clinical pathology characteristics. Methods：We retrospectively analyzed 52 cases of gastric cancer patients from Feb 2011 to Oct 2015 in our hospital. The cancer tissue and relative normal gastric tissue were tested for EGFR expression by immunohistochemical method. The clinical pathology characteristic prognosis with EGFR expression were evaluated by statistical software. Results： The EGFR positive expression in cancer tissue and relative normal tissue were 46.2% （24/52） and 21.40//00（6/28） which indicated cancer tissue much higher than normal tissue（P〈0. 05）. The EGFR positive expression were associated with tumor diameter, invasion depth and lymph node metastasis（P〈0. 05）. The median survival for EGFR positive and negative patients were 17. 2 months and 25.4 months（HR=2. 01,95%CI： 1.22-3. 84）. Conclusion： EGFR was highly expressed in cancer tissue and associated with poor prognoss.

关 键 词：表皮生长因子受体 胃癌 预后 临床意义 

分 类 号：R735.2[医药卫生—肿瘤]