DNA结合抑制因子1在非小细胞肺癌发生、发展中的作用分析  

Function Analysis of DNA Binding Inhibitor 1 in the Occurrence and Development of Non Small Cell Lung Cancer

作　　者：彭旭兴[1] 

机构地区：[1]北京大学深圳医院,广东深圳518036

出　　处：《中国医学创新》2016年第17期41-43,共3页Medical Innovation of China

基　　金：2011年深圳市科技计划项目(201103012)

摘　　要：目的:分析DNA结合抑制因子1(Id1)在非小细胞肺癌发生、发展中的作用。方法:选取2013年10月-2015年9月本院收治的非小细胞肺癌的患者41例为非小细胞肺癌组,选择同期在本院就诊的肺部良性病变的患者40例为良性病变组,再选择同期在本院进行健康体检的受检者42例为健康组。三组受检者均进行免疫组化S-P法检查,观察三组受检者肺组织中Id1的表达情况。结果:非小细胞肺癌组中Id1的表达率为95.12%,显著高于良性病变组的2.5%和健康组的0(P<0.05);非小细胞肺癌组织不同分化程度Id1蛋白阳性表达率比较差异有统计学意义(P<0.05),且癌组织Id1蛋白阳性表达率随着分化程度的降低而升高(P<0.05);肺鳞癌和肺腺癌、瘤体直径≤3 cm和瘤体直径>3 cm、淋巴结转移不同时期的Id1蛋白阳性表达率比较差异无统计学意义(P>0.05)。结论:Id1与非小细胞肺癌发生、发展有着密切的关系,且其表达水平与非小细胞肺癌癌细胞的分化程度呈负相关,可作为诊断非小细胞肺癌的重要标志物。Objective：To analyze the role of DNA binding inhibitor 1（Id1） in the occurrence and development of non small cell lung cancer.Method：From October 2013 September 2015, 41 cases of non small cell lung cancer in our hospital were selected as non small cell lung cancer group, the same period in our hospital of 40 patients with benign lung disease were selected as benign lesion group,and then the same period 42 cases of healthy subjects were selected in our hospital as healthy group.The three groups were examined by immunohistochemistry S-P method, and the expression of Id1 in the three groups were observed.Result：The rate of expression of Id1 in the small cell lung cancer group was 95.12%,significantly higher than that of the benign lesion group of 2.5% and the health group and 0（P〈0.05）.The non small cell lung cancer group with different degree of differentiation of Id1 protein positive expression rate of difference significant（P〈0.05）,and carcinoma Id1 protein positive expression rate decreased with the degree of differentiation and increased（P〈0.05）.Lung squamous cell carcinoma and adenocarcinoma of lung cancer,tumor diameter was less than or equal to 3 cm and tumor diameter3 cm,lymph node transfer in different periods of Id1 protein positive expression rate of the difference were not significant（P〈0.05）.Conclusion：Id1 and non small cell lung cancer, the development of a close relationship,and the expression level and non small cell lung cancer cell differentiation were negative correlation,which can be used as a diagnosis of non small cell lung cancer marker.

关 键 词：非小细胞肺癌 DNA结合抑制因子1 肿瘤的发生和发展 免疫组化S-P法 

分 类 号：R734.2[医药卫生—肿瘤]