乳腺癌术后化疗患者感染的影响因素分析  

Risk factors of infection induced by postoperative chemotherapy in breast cancer patients

作　　者：龚烨[1] 李炳军[2] 姚亚峰[2] 

机构地区：[1]新疆维吾尔自治区人民医院乳腺甲状腺二科,乌鲁木齐830001 [2]太原市妇幼保健院外科,太原0300120

出　　处：《癌症进展》2016年第4期393-395,共3页Oncology Progress

摘　　要：目的分析乳腺癌患者术后化疗发生感染的影响因素,并提出相应的干预对策。方法回顾性分析268例乳腺癌术后化疗患者的感染可能相关因素,并对相关因素进行Logistic分析。结果本研究患者感染率为17.16%,其中呼吸道感染20例,皮肤软组织感染9例,口腔黏膜感染7例,其他感染10例;经Logistic回归分析,化疗周期﹥3个,抗菌使用药物﹥2种,白细胞计数﹤4×10~9/L,血清白蛋白﹤35 g/L,CD4^+/CD8^+值﹥1.33,年龄≥60岁,行乳腺癌扩大根治术是乳腺癌患者术后化疗发生感染的危险因素,差异有统计学意义(P﹤0.01)。结论对于白细胞计数过低,化疗3个周期以上,免疫力低下的乳腺癌术后化疗老年患者应采取积极预防措施。Objective To analyze the risk factors of infection caused by postoperative chemotherapy in breast cancer patients, and to establish management accordingly. Method 268 cases of breast cancer patients who had developed infec-tion of postoperative chemotherapy that were treated in our hospital were retrospectively analyzed, the correlation be-tween related factors and postoperative infection was investigated using Logistic analysis. Result The infection rate in all patients was 17.16%, and there were 20 cases of respiratory tract infection, 9 cases of skin and soft tissue infection, 7 cases of oral mucosal infection, and 10 cases of other infection;the multivariate Logistic regression analysis showed that, chemotherapy cycle〉3, antibacterial medication〉2, white blood cell count〈4x109/L, serum albumin〈35 g/L, CD4＋/CD8＋〉1.33, age≥60, breast cancer extended radical resection were significant risk factors concerning postoperative infection caused by chemotherapy in patients with breast cancer （P〈0.01）. Conclusion For elderly immunocompromised patients who have abnormally low white blood cell count and underwent more than three cycles of chemotherapy, infection con-trol precautions should be actively taken.

关 键 词：乳腺癌 化疗 感染 影响因素 

分 类 号：R737.9[医药卫生—肿瘤]