早产儿治疗用氧和早产儿视网膜病变的相关性研究  

Study on the relationship between the treat in preterm infant with oxygen and retinopathy of prematurity

作　　者：苏艳兰[1] 陈均[1] 欧小燕[1] 

机构地区：[1]广东省茂名市妇幼保健院,广东茂名525500

出　　处：《吉林医学》2016年第6期1347-1349,共3页Jilin Medical Journal

基　　金：广东省茂名市科技计划项目[项目编号:20150336]

摘　　要：目的：探讨早产儿治疗用氧和早产儿视网膜病变（ROP）的相关性。方法：选取需要吸氧的早产儿分为A组（78例）、B组（50例）和C组（36例）,A组、B组和C组的氧浓度分别为≤29%、30%～39%和≥40%。统计在各种氧浓度、吸氧时间（包括吸氧〈10 d和吸氧≥10 d）和血氧饱和度（包括低血氧饱和度与高血氧饱和度）中的ROP发病情况,利用χ2检验分析数据。结果：C组的Ⅱ期病变构成比、C组和B组的ROP发病率均明显高于A组,差异有统计学意义（P〈0.05）;与吸氧〈10 d ROP患儿相比,吸氧≥10 d ROP患儿的I期病变构成比明显低,而Ⅲ期～Ⅳ期病变构成比则明显高,差异有统计学意义（P〈0.05）;高血氧饱和度ROP患儿的Ⅲ期～Ⅳ期病变构成比明显高于低血氧饱和度ROP患儿,差异有统计学意义（P〈0.05）。结论：降低氧浓度、减少吸氧时间和保持较低的血氧饱和度有利于降低ROP的发病率和减轻ROP病情,但早产儿医疗用氧应个体化。Objective To investigate the relationship between the treatment in preterm infant with oxygen and retinopathy of prematurity（ ROP）. Method Premature infant patients who need oxygen,which were divided into group A（ 78 cases）,group B（ 50cases） and group C（ 36 cases）. Oxygen concentration of group A,B,C were ≤29%,30% ～ 39% and ≥40%,respectively. The incidence of ROP in different oxygen concentration,oxygen inhalation time（ include oxygen inhalation time 10 days and oxygen inhalation time ≥10 days） and blood oxygen saturation（ include lower target range of oxygenation and high target range of oxygenation） were be statistical,using chi- square test to analyze the data. Results As compared with group A,significantly raise up of the constituent ratio of ⅡStage pathological changes in the group C,and the incidence rate of ROP in the group B and group C also increased obviously（ P〈0. 05）. As compared with oxygen inhalation time 10 days preterm infant,significantly decrease the incidence rate ofⅠStage pathological changes,and the constituent ratio of Ⅲ ～ Ⅳ Stage pathological changes were apparently higher in the oxygen inhalation time≥10 days preterm infant（ P〈0. 05）. The constituent ratio of Ⅲ ～ Ⅳ Stage pathological changes in the higher target range of oxygenation was apparently higher than lower target range of oxygenation（ P〈0. 05）. Conclusion Reducing the oxygen concentration,reducing the oxygen inhalation time and keeping lower target range of oxygenation are profit to decrease the incidence rate of ROP and reducing ROP＇s condition,but treat in preterm infants with oxygen would individualization.

关 键 词：早产儿视网膜病变 早产儿 吸氧浓度 吸氧时间 血氧饱和度 

分 类 号：R774.1[医药卫生—眼科]