P13K／Akt／mTOR信号转导通路与肿瘤  

PI3K/Akt/mTOR signal transduction pathway and tumor

作　　者：周笑[1,2] 杨鹏[3,4] 于雁[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院肿瘤内科,150081 [2]黑龙江省大庆油田总医院肿瘤科 [3]哈尔滨医科大学附属第二医院胸外科,150086 [4]黑龙江省大庆油田总医院胸外科

出　　处：《国际免疫学杂志》2016年第3期280-284,共5页International Journal of Immunology

摘　　要：近年来，信号转导通路与肿瘤已成为了研究热点，而无论在生理还是病理条件下磷脂酰肌醇3激酶和哺乳动物雷帕霉素靶蛋白（P13K／Ak∥rnTOR）信号转导通路在抑制凋亡、促进增殖方面都是一条重要的信号转导通路，并且P13K／Akt／mTOR信号传导通路在肿瘤治疗的研究中同样也发挥着重要作用。因而，研究P13K／Akt／mTOR信号转导通路和主要组成部分以及P13K、Akt、mTOR抑制剂具有重要意义。In recent years, signal transduction pathway and tumor has become an investigative hotspot. In both physiological and pathological conditions, PI3K/Akt,/mTOR signal transduction pathway is important in inhibiting apoptosis and promoting proliferation. This pathway also plays an important role in tumor treatment. Thus, the research on the main components of this pathway and the inhibitors of PI3K, Akt, and mTOR has im- portant significance.

关 键 词：P13 K/Akt/mTOR 信号转导通路 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]