O型血孕妇IgG抗A(B)效价监测与新生儿溶血病相关性分析  

Pregnant women with type 0 blood Ig G against A(B)titer monitoring and neonatal hemolysis disease correlation analysis

作　　者：唐勇[1] 吴世园[1] 唐琳[1] 王武[1] 

机构地区：[1]湖南省怀化市妇幼保健院,湖南怀化418000

出　　处：《中国优生与遗传杂志》2016年第6期68-69,73,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血型不合夫妇中O型血孕妇Ig G抗A(B)效价监测与新生儿溶血病(HDN)关系。方法采用微柱凝胶技术检测2135例夫妇ABO血型不合的O型Rh-D阳性血孕妇Ig G抗A(B)效价,观察抗体分布情况及抗体效价与新生儿溶血病相关性。结果 2135名孕妇中,881例Ig G抗A效价≥64有550例,773例Ig G抗B效价≥64有402例,481例Ig G抗A/B效价≥64有220例。发生ABO-HDN的有225例,发病率为10.5%,发生新生儿溶血病患儿母亲抗体效价范围256-1024,患儿发病率有随母体抗体效价升高而明显上升,Ig G抗A、Ig G抗B效价为512时发病率明显升高,P<0.05,Ig G抗AB效价为256时发病率明显升高,P<0.05。结论新生儿溶血病发病率随着孕妇抗体效价增高而增加,孕妇Ig G抗A(B)效价≥256时有发生ABO-HND的可能性,孕妇Ig G抗A(B)效价≥512的孕妇所产新生儿发生ABO-HND的可能性较大,临床应该进行效价的定期检测。Objective： To study the blood not couples fight A type O blood in pregnant women IgG titer monitoring （B） relationship with newborns hemolytic disease （HDN） . Methods： Using micro column gel technology to detect 2135 cases of couple of ABO blood group is O Rh-D fight A positive pregnant women blood IgG titer （B） , to observe the distribution of the antibody and antibody titer and neonatal hemolytic disease. Results： 2135 cases in 2135 pregnant women, IgG against A titer of 64 or more in 550 patients, 773 cases of IgG anti B titer in 64 patients, 64 or higher or greater resistance to A/B, 481 cases of IgG titer of 64 with 220 cases. ABO HDN-225, was 10.5%, the incidence of neonatal hemolysis disease occurred in children with mother antibody titer range 256-256, with rates have increased dramatically, with maternal antibody titer IgG resistance against A, IgG titer of 512 B incidence increased significantly, P〈 0.05, IgG AB titer of 256 when the incidence increased significantly, P〈0.05） .Conclusions： Neonatal hemolysis disease incidence increased with pregnant women increased antibody titer, resistance to A pregnant woman IgG titer （B） 256 or higher to happen from time to tome ABO-the possibility of HND, resistance to A pregnant woman IgG titer of 512 or （B） newborn from the pregnant women more likely to happen ABO-HND, clinical should take titer of testing on A regular basis.

关 键 词：微柱凝胶技术 IG G抗A(B) 新生儿溶血病 

分 类 号：R722.18[医药卫生—儿科]