DDR1在唾液腺黏液表皮样癌中的表达及意义  

Expression and significance of discoidin domain receptor 1 in salivary gland mucoepidermoid carcinoma

作　　者：王智明[1] 温惠媛 杨东升[1] 叶明[1] 潘遥 马颖[2] 张力平[1] 

机构地区：[1]中国医科大学附属盛京医院口腔颌面外科,辽宁沈阳110004 [2]中国医科大学附属盛京医院病理科,辽宁沈阳110004

出　　处：《上海口腔医学》2016年第3期322-326,共5页Shanghai Journal of Stomatology

基　　金：辽宁省科学技术计划项目资助(2012225100)

摘　　要：目的 :探讨盘状结构域受体1(discoidin domain receptor 1,DDR1)在唾液腺黏液表皮样癌(mucoepidermoid carcinoma,MEC)中的表达及意义。方法 :采用免疫组织化学和Western免疫印迹技术检测MEC细胞株M3SP2和MC3中DDR1的表达情况。应用免疫组织化学方法检测58例唾液腺MEC组织及20例正常唾液腺组织中DDR1的表达,采用SPSS13.0软件包对数据进行统计学分析。结果:DDR1在黏液表皮样癌组织中的阳性表达率为79.3%,显著高于正常唾液腺组织(10%,P<0.01)。DDR1的高表达与MEC的临床病理参数无显著相关性(P>0.05)。在黏液表皮癌细胞株M3SP2和MC3中,DDR1表达阳性。结论:DDR1在唾液腺MEC的发生、发展中可能发挥重要作用。PURPOSE： To investigate the expression and significance of discoidin domain receptor 1（DDR1） in salivary gland mucoepidermoid carcinoma（MEC）. METHODS： Immunohistochemical and Western blot method were used to detect the expression of DDR1 in MEC M3SP2 and MC3 cell lines. Immunohistochemical method was used to detect the expression of DDR1 in 58 MEC and 20 normal salivary gland tissues. SPSS 13.0 software package was used for statistical analysis. RESULTS： The positive expression rate of DDR1 in salivary gland MEC tissues was 79.3%, significantly higher than 10.0% in normal salivary gland tissues（P〈 0.01）. High expression of DDR1 was not related to clinicopathological parameters of MEC（P〉0.05）. The expression of DDR1 was positive in MEC M3SP2 and MC3 cell lines. CONCLUSIONS：DDR1 may play an important role in carcinogenesis and progress of salivary gland MEC.

关 键 词：盘状结构域受体1 唾液腺 黏液表皮样癌 

分 类 号：R739.87[医药卫生—肿瘤]