养血清脑颗粒治疗急性脑梗死的临床效果及对血液流变学指标的影响  

Clinical efficacy of Yangxue Qingnao Granules in the treatment of acute cerebral infarction and the influence on the blood indexes

作　　者：高爱民[1] 刘永刚[1] 齐伟静[1] 邢晓明[1] 王宁[1] 

机构地区：[1]河北省保定市第一中心医院神经内科,河北保定071000

出　　处：《中国医药导报》2016年第16期90-93,97,共5页China Medical Herald

基　　金：河北省中医药管理局科研计划项目(2014328)

摘　　要：目的 探讨养血清脑颗粒治疗急性脑梗死的临床效果及对血液流变学指标的影响。方法 将2013年12月～2015年9月河北省保定市第一中心医院收治的98例急性脑梗死患者随机分为观察组（50例）和对照组（48例）,对照组采用常规方法治疗,观察组在上述治疗的基础上加用养血清脑颗粒治疗,比较两组临床疗效、治疗前后美国国立卫生研究院卒中量表（NIHSS）评分、Barthel指数（BI）及血液流变学指标变化情况。结果 观察组显效率为90.0%（45/50）,总有效率为98.0%（49/50）,均明显高于对照组的72.9%（35/48）、87.5%（42/50）,差异均有统计学意义（均P〈0.05）。两组治疗后NIHSS评分均较治疗前明显降低,BI评分均治疗前明显升高,差异均有统计学意义（均P〈0.05）,且观察组治疗后NIHSS评分明显低于对照组,BI评分明显高于对照组,差异均有统计学意义（均P〈0.05）。两组治疗后全血高切黏度、全血低切黏度、血细胞比容、血浆黏度及红细胞聚集指数均较治疗前明显降低,且观察组治疗后上述指标均明显低于对照组,差异均有统计学意义（均P〈0.05）。结论 养血清脑颗粒治疗急性脑梗死可有效改善血液流变学指标,促进神经功能恢复,疗效显著,值得临床推广应用。Objective To investigate the clinical efficacy of Yangxue Qingnao Granules in the treatment of acute cerebral infarction and the influence on the blood indexes. Methods Ninety eight cases of patients with acute cerebral infarction admitted to Baoding First Central Hospital from December 2013 to September 2015 were randomly divided into the observation group （50 cases） and the control group （48 cases）, the control group was treated with routine method, the observation group was treated with Yangxue Qingnao Granules on the basis of conventional treatment. The clinical efficacy, national institutes of health stroke scale （NIHSS）, Barthel index （BI） and changes of hemodynamic indexes before and after treatment in the two groups were compared. Results The obvious effective rate of observation group was 90% （45/50）, the total effective rate was 98% （49/50）, which were significantly higher than those of control group [72.9% （35/48）, 87.5% （42/50）], the differences were all statistically significant （all P 〈 0.05）. The NIHSS scores of the two groups after treatment were all lower than those before treatment and BI scores were higher than those before treatment, the differences were all statistically significant （all P 〈 0.05）, and the NIHSS score of observation group after treatment was lower than that of control group, BI score was higher than that of control group, the differences were all statistically significant （P 〈 0.05）. Compared with before treatment,the high blood viscosity, low blood viscosity, haematocrit, plasma viscosity and erythrocyte aggregation index of the two groups after treatment were significantly decreased, and the indexes of the observation group after treatment were significantly lower than those of control group, the differences were all statistically significant （all P 〈 0.05）. Conclusion The treatment of Yangxue Qingnao Granules on acute cerebral infarction can effectively improve the indexes of hemorheology, promote the recovery of neur

关 键 词：养血清脑颗粒 急性脑梗死 临床疗效 血液流变学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]