外泌体在肿瘤转移及诊疗中的研究进展  

Progress of Exosomes in Tumor Metastasis and Diagnosis

作　　者：李孟娇[1,2] 王浩[1,2] 李庆伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院 [2]辽宁师范大学七鳃鳗研究中心,大连116081

出　　处：《中国细胞生物学学报》2016年第5期608-615,共8页Chinese Journal of Cell Biology

基　　金：辽宁师范大学青年科研项目(批准号:LS2014L011)资助的课题~~

摘　　要：外泌体是直径为40～130nm的纳米级囊泡结构，其中包含有大量的蛋白质、核酸和脂质等，在细胞间物质信息传递过程中发挥重要的作用。与正常细胞相比，肿瘤细胞释放更多的外泌体，并且其中所包含的一系列蛋白质和核酸组分（包括miRNAs）在调节肿瘤微环境、促进肿瘤的转移侵袭过程中起到了关键的作用。该文重点介绍了由外泌体所介导的整合蛋白、表皮生长因子受体和miRNAs等分子在细胞间的转运对于肿瘤转移和侵袭的影响，并展望了外泌体在肿瘤的诊断和治疗方面的应用前景。随着研究的深入，通过外泌体建立有效的早期诊断体系和诊疗方案将为肿瘤的治疗提供新的思路和方法。Exosomes are nano-scale membrane vesicles （40-130 nm in diameter） secreted by a variety of cells, which contain a large amount of proteins, nucleic acids, lipids and so on. It plays an important role in the process of intercellular communication. Compared with normal cells, cancer cells release more exosomes, which contain a series of proteins and nucleic acid components （including microRNAs） involved in the regulation of tumor micro-environment and promoting tumor invasion and metastasis. Here, we focus on the functions of integrin, EGFR, microRNAs and other molecular cargoes mediated by exosomes derived from cancer cells on cancer invasion and metastasis. Then we introduced the application perspective of exosomes in the diagnosis and treatment of cancer. The breakthrough in an emerging role of cancer cells-derived exosomes will promote development of novel approaches for effectiveearly diagnosis and therapeutic strategies of cancer.

关 键 词：外泌体 肿瘤 转移 诊断 治疗 

分 类 号：R73-3[医药卫生—肿瘤]