肥胖影响乳腺癌的研究进展  

Progress in the Impact of Obesity on Breast Cancer

作　　者：许静凯 陈梦云[1] 许奕荟 徐明贵[1] 黄鹤群[1] 刘臣[1] 张博[1] 

机构地区：[1]安徽医科大学第二附属医院,安徽合肥230601

出　　处：《肿瘤学杂志》2016年第6期462-466,共5页Journal of Chinese Oncology

基　　金：国家自然青年科学基金项目(81301771)

摘　　要：研究表明肥胖可能会影响乳腺癌的发病和预后,但是影响机制尚未明确。本文搜集整理了近年来肥胖与不同绝经状态、不同分子亚型乳腺癌之间发病和预后的关系研究。其中肥胖对绝经前和绝经后乳腺癌的影响是不同的,同时肥胖对不同分子亚型乳腺癌患者发病和预后的影响亦是不同的,并且肥胖合并糖尿病等其他疾病也导致乳腺癌的预后更差。本文对这些文献加以总结并搜集了一些肥胖对乳腺癌发病机制影响的相关研究,可对肥胖与乳腺癌之间关系的基础研究和临床工作提供更多的参考依据。Studies indicate that obesity may influence the pathogenesis and prognosis of breast cancer,but mechanism is not yet clear. We have collected a series of recent researches of the relationship between obesity and pathogenesis and prognosis of breast cancer in different menopausal status and subtypes. Obesity influences pre-menopausal and post-menopausal breast cancer respectively. The impacts of obesity on morbidity,mortality and prognosis of breast cancer patients in different subtypes are not the same. Moreover,complications such as diabetes result in poor prognosis. By summarizing some mechanism researches,it would provide more referential basis for future researches and clinical works.

关 键 词：乳腺肿瘤 肥胖 绝经 分子分型 发病 预后 

分 类 号：R737.9[医药卫生—肿瘤]