肿瘤放射治疗的免疫效应  

The immune effect of radiotherapy on tumor

作　　者：张玉宇[1] 李戈[2] 刘百龙[1] 姜新[1] 龚守良[3] 董丽华[1] 

机构地区：[1]吉林大学第一医院放疗科,长春130021 [2]长春市中医院内分泌科,长春130041 [3]吉林大学公共卫生学院卫生部放射生物学重点实验室,长春130021

出　　处：《中华放射医学与防护杂志》2016年第6期470-474,共5页Chinese Journal of Radiological Medicine and Protection

摘　　要：近些年,免疫学者已注意到电离辐射对肿瘤免疫的效应,并试图探讨其诱导和改善抗肿瘤免疫效应。越来越多的证据表明,采用确切的放疗方案和有效的照射剂量,特别是与免疫治疗联合应用,能够诱导或调节全身免疫反应,有助于肿瘤的控制或炎性反应的发生。本文综述放疗对肿瘤免疫效应及其机制,以及与免疫治疗联合应用效果,以期指导肿瘤放疗与免疫治疗的有效联合应用。Recently, immunologists have payed the attention to the effects of ionizing radiation on tumor immunity, and attempted to induce and improve anti-tumor immune effects with it. More and more evidences showed that by adopting exact radiotherapy scheme and irradiation dose, particularly combined with immunotherapy, could induce or regulate systemic immune response and contributed to tumor control and inflammatory occurrence. This paper reviewed the effects and mechanisms of radiotherapy on tumor immune and the results in combination with immunotherapy here for guiding the effective combined application of radiotherapy and immunotherapy.

关 键 词：肿瘤 放射治疗 免疫治疗 免疫反应 

分 类 号：R730.55[医药卫生—肿瘤]