STAT3与辐射敏感相关性的研究进展  

Research progresses of correlation between STAT3 and radiosensitivity

作　　者：陈晓艳[1] 张江虹[1] 邵春林[1] 

机构地区：[1]复旦大学放射医学研究所放射生物研究部,上海200032

出　　处：《国际放射医学核医学杂志》2016年第3期191-195,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（31570850,81273001,11179002,31200631）

摘　　要：放疗是肿瘤治疗的主要方法之一，但肿瘤的辐射抵抗是影响放疗疗效的一个重要原因。信号转导和转录激活因子3（STAT3）是STAT家族的重要成员，与肿瘤的发生、发展紧密相关。电离辐射可以对STAT3的表达水平产生影响，同时STAT3的表达水平也可反作用于细胞，通过对肿瘤细胞DNA损伤、自噬、凋亡、增殖、血管生成、迁移、侵袭、免疫抑制等的调节影响其辐射敏感性，这预示着以STAT3为突破口的辐射敏感性研究将会为肿瘤临床治疗提供新策略。Radiotherapy is one of the main methods in cancer treatment, but the tumor radioresistance is a main point influencing the efficiency of radiotherapy. STAT3 is an important member of the STAT family and it is closely correlated with tumor incidence and development.The expression of STAT3 can he altered by ionizing radiation and hence it could affect radiosensitivity of tumour cells by regulating DNA damage, autophagy, apoptosis, proliferation, angiogenesis, migration, invasion and immune suppression. Accordingly,the deep understanding the role of STAT3 in radiation sensitivity may provide a new strategy for clinical cancer therapy.

关 键 词：STAT3转录因子 肿瘤 放射疗法 辐射耐受性 

分 类 号：R730.55[医药卫生—肿瘤]