地拉罗司有关物质的合成  

Synthesis of the related substances of deferasirox

作　　者：罗艳[1] 古金华[1] 罗志腾[1] 吴杰[1] 叶连宝[1] 

机构地区：[1]广东药科大学药科学院,广州510006

出　　处：《中国药科大学学报》2016年第3期288-290,共3页Journal of China Pharmaceutical University

基　　金：广东省科技计划资助项目;广东省自然科学基金资助项目(No.2015A030313586)~~

摘　　要：为控制地拉罗司的药品质量,建立地拉罗司原料药的质量标准,从地拉罗司的合成路线入手,分析并合成其中可能存在的3个有关物质:2-(2-羟苯基)-4H-苯并[1,3-e]嗪-4-酮(A)、2-羟基-N-(2-羟基苯甲酰基)-苯甲酰胺(B)、4-[3,5-二(2-羟基苯基)-1H-1,2,4-三氮唑-1-基]苯甲酸甲酯(C),并经1H NMR和MS确证结构。To perform the quality control of deferasirox and establish its quality criterion, three related substances which were determined by analyzing the synthetic route were synthesized, and their structures were confirmed by 1H NMR and MS. These substances were 2-（2-hydroxyphenyl）-4H-benzo［1, 3-e］oxazin-4-one（A）, 2-hydroxy-N-（2-hydroxyben-zoyl）-benzamide（B）, and methyl-4-［3, 5-bis（2-hydroxyphenyl）- 1H- ［1, 2, 4］triazol-1-yl］-benzoate（C）.

关 键 词：地拉罗司 有关物质 合成 

分 类 号：R914.5[医药卫生—药物化学]