进展性脑卒中应用阿托伐他汀治疗的效果分析  

Effect Analysis on Atorvastatin in the Treatment of Progressive Stroke

作　　者：彭铁生[1] 

机构地区：[1]广东省高州市人民医院,广东茂名525200

出　　处：《临床医学工程》2016年第6期747-748,共2页Clinical Medicine & Engineering

摘　　要：目的探讨进展性脑卒中应用阿托伐他汀治疗的临床效果。方法选取我院2014年3月至2015年3月收治的120例进展性脑卒中患者为研究对象,随机分为对照组和治疗组,每组分别为60例。对照组采用常规治疗,治疗组在此基础上给予阿托伐他汀治疗。采用神经功能缺损评分(NIHSS)评估患者的神经功能损伤程度,并比较两组患者的血脂水平,包括总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)等。结果经治疗后,治疗组患者的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)水平均显著低于对照组,高密度脂蛋白(HDL)水平显著高于对照组,差异具有统计学意义(P<0.05)。治疗组患者神经功能缺损(NIHSS)评分为(11.6±2.7)分,显著低于对照组的(16.8±2.5)分,差异具有统计学意义(t=10.946,P<0.05)。结论阿托伐他汀治疗进展性脑卒中效果显著,治疗过程中未发现严重不良反应,值得推广和深入研究。Objective To study the clinical effect of atorvastatin in the treatment of progressive stroke. Methods 120 cases of patients with progressive stroke treated in our hospital from March 2014 to March 2015 were selected as research subjects and randomly divided into control group and treatment group, with 60 cases in each group. The control group was treated with conventional therapy, the treatment group was treated with atorvastatin on the basis of control group. The degree of neurological function impairment was evaluated by NIHSS, the level of blood lipid [including total cholesterol （TC）, triacylglycerol （TG）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL）] were compared between two groups. Results After treatment, the levels of TC, TG and LDL in treatment group were significantly lower than those in control group, and the level of HDL in treatment group was significantly higher than that in control group, all the difference was statistically significant （P〈0.05）. The NIHSS score of treatment group was （11.6 ± 2.7） points, significantly lower than （16.8 ± 2.5） points of control group, with statistically significant difference （t = 10.946, P〈0.05）. Conclusions Atorvastatin has significant effect in the treatment of progressive stroke, without serious adverse reactions in the process of treatment, which is worthy of popularization and deep research.

关 键 词：进展性脑卒中 阿托伐他汀 治疗应用 效果分析 

分 类 号：R743.32[医药卫生—神经病学与精神病学]