针刺通过催产素和精氨酸加压素治疗焦虑障碍的作用机制分析  

Mechanism of the Treatment of Anxiety Disorders by Acupuncture Through Oxytocin and Arginine Vasopressin

作　　者：魏京金 蔡定均[1] 周奇志[1] 余曙光[1] 赵纪岚[1] 肖夏[1] 魏大能[1] 姚弘[1] 杨名己 谢光春 

机构地区：[1]成都中医药大学针灸推拿学院,四川省成都市610075

出　　处：《中国全科医学》2016年第16期1981-1985,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(81173322)

摘　　要：焦虑障碍严重危害人类的健康,其发病机制及干预措施已经成为针灸等医学领域的研究热点。催产素(oxytocin,OT)具有抗焦虑的效应;与之相反,精氨酸加压素(arginine vasopressin,AVP)具有致焦虑的作用。针刺的抗焦虑效应早已被证实,但针刺的作用机制尚未完全明了,针刺通过OT及AVP治疗焦虑障碍的相关机制研究也罕见报道。本文从OT与焦虑障碍的关系、AVP与焦虑障碍的关系、OT-AVP与焦虑障碍的关系、OT-AVP在针刺抗焦虑中的新机制4个方面,探讨针刺通过OT-AVP治疗焦虑障碍的作用机制,为针刺抗焦虑的机制研究拓展新方向。Anxiety disorder brings severe harm to human health,thus its pathogenesis and intervention measures have become hot spots of study in many fields such as acupuncture and moxibustion. Oxytocin（ OT） has anti- anxiety effect,whereas arginine vasopressin（ AVP） causes anxiety. The antianxiety effect of acupuncture has long been confirmed,but its mechanism has not been completely known, and there are rare reports about the relevant mechanism of the treatment of anxiety disorder by acupuncture through OT and AVP. The paper explain in four aspects which are the relation between OT and anxiety disorder,the relation between AVP and anxiety disorder,the relation between OT- AVP and anxiety disorder,and the mechanism of OT-AVP in the treatment of anxiety by acupuncture. We investigated the mechanism of the treatment of anxiety disorder by acupuncture through OT- AVP,in order to provide new directions for relevant research.

关 键 词：针刺 焦虑障碍 催产素 精氨酸加压素 

分 类 号：R749.72[医药卫生—神经病学与精神病学] R245.31[医药卫生—临床医学]