北京市平谷区新型农村合作医疗农民肺癌实验室肿瘤标志物联合检测筛查结果分析  

Analysis of combined detection and screening of lung cancer tumor markers for rural citizens in ＂New Rural Cooperative Medical System＂ in Beijing Pinggu district

作　　者：张欣 刘倩[2] 谢志贤[2] 

机构地区：[1]北京市平谷区中医医院检验科,101200 [2]北京医院检验科,100730

出　　处：《中国医药》2016年第7期1000-1003,共4页China Medicine

摘　　要：目的分析北京市平谷区新型农村合作医疗农民肺癌实验室肿瘤标志物联合检测筛查结果。方法选择北京市平谷区2012年1月至2013年12月35～75岁的新型农村合作医疗农民11258人为研究对象。参考临床症状同时检测癌胚抗原、血清鳞状上皮相关抗原（SCC）水平进行肺癌筛查，最后经低剂量螺旋CT和病理检查确诊。分析肺癌发病情况及其年龄、患病危险因素分布，癌胚抗原、SCC水平及阳性表达情况。结果11258人中共检出肺癌（肺癌组）22例（0．2％），其中男20例、女2例。肺部良性病变（肺部良性病变组）7018例（62．3％），其中男5671例、女1347例；健康人群（健康组）4218人（37．5％），其中男2421人、女1797人。65岁以上肺癌占比最高，占59．1％（13／22）。35～50、51～65、〉65岁患者男、女发病率差异均有统计学意义[0．20％0（2／11258）比0．00‰（0／11258）、0．50‰（6／11258）比0．09‰（1／11258）、1．10‰（12／11258）比0．09‰（1／11258），P〈0．05]。平谷区农民患肺癌的最主要危险因素为年龄因素，其次为吸烟因素，第三是地理气候因素。肺癌组癌胚抗原、SCC水平明显高于肺部良性病变组和健康组[（25．6±3．2）μg/L比（3．2±0．9）、（3．4±0．8）μg/L，（2．3±0．7）μg/L比（1．3±0．3）、（0．8±0．3）μg/L]，差异有统计学意义（P〈0．05）。肺癌组癌胚抗原与SCC联合检测阳性表达率明显高于单独检测癌胚抗原或SCC[86．4％（19／22）比72．7％（16／22）、63．6％（14／22）]，差异有统计学意义（P〈0．05）。结论血清癌胚抗原和SCC肿瘤标志物联合检测可明显提高肺癌诊断的敏感度，可满足新型农村合作医疗患者筛查需求。Objective To analyze the detection and screening results of lung cancer tumor markers for rural citizens in＂ New Rural Cooperative Medical System＂ in Beijing Pinggu district. Methods Totally 11 258 people with ages of 35-75 in＂ New Rural Cooperative Medical System＂ from January 2012 to December 2013 in Beijing Pinggu district were selected. Clinical symptoms were observed and serum levels of carcino-embryonic antigen（CEA） , Squamous cell carcinoma antigen（SCC） were detected to screen lung cancer which was finally di- agnosed by low dose spiral CT and pathological examination. The occurrence of lung cancer and age, risk factors distribution, levels and positive expressions of CEA and SCC were analyzed. Results In 11 258 people, totally 22 cases（0. 2% ）were diagnosed of lung cancer （lung cancer group）, including 20 males and 2 females; totally 7 018 eases （62.3%）were diagnosed of benign lung disease （benign long disease group ）, including 5 671 males and 1 347 females; other 4 218 healthy people（37.5% ）were enrolled as health control group, including 2 421 males and 1 797 females. People over 65 years old had the highest proportion of lung cancer, which was 59. 1% （ 13/22 ）. Incidences of lung cancer between male and female in people with ages of 35-50, 51-65 and over 65 had statistically significant differences [ 0. 20‰（ 2/11 258 ） vs 0. 00‰ （ 0/11 258 ）, 0. 50‰ （ 6/11 258 ） vs 0.09‰ （ 1/11 258）, 1.10‰（ 12/11 258 ） vs 0. 09‰（ 1/11 258） ] （P 〈 0, 05 ）. The main risk of lung cancer among rural citizens in Pinggu district was age, followed by smoking and environmental factors. Levels of CEA and SCC in lung cancer group were significantly higher than those in benign lung disease group and healthy control group[ （25.6 ±3.2）μg/L vs（3.2 ±0. 9）, （3.4 ±0. 8） μg/L; （2.3 ±0.7） μg/L vs（ 1.3 ± 0.3）, （0. 8 ± 0. 3）μg/L] （P 〈0. 05 ）. Positive expressions of CEA and SCC with combined detection were significantl

关 键 词：肺癌 肿瘤标志物 新型农村合作医疗 

分 类 号：R734.2[医药卫生—肿瘤]