宽波电脉冲电针足三里防治下肢肌萎缩研究  

Study of Wide Pulse Wave Electroacupuncture at Zusanli(ST36) for Preventing and Treating Lower Limb Muscle Atrophy

作　　者：庄伊洢[1] 陈玄[1] 叶笑然[1] 黄晓卿[1] 

机构地区：[1]福建省中医药研究院,福州350003

出　　处：《上海针灸杂志》2016年第6期742-744,共3页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家自然科学基金面上项目(81373733);福建省卫生厅中医药科研项目(wzzh201306);福建省属公益类科研院所基本科研专项(2015R1035-4)

摘　　要：目的筛选电针防治肌萎缩的优化电脉冲波宽。方法将40只大鼠制作成下肢肌萎缩模型,分为Ⅰ组(不电针)、Ⅱ组(波宽0.5 ms,频率2 Hz)、Ⅲ组(波宽100 ms,频率2 Hz)、Ⅳ组(波宽200 ms,频率2 Hz),电针足三里和承山穴。以坐骨神经功能指数(SFI)、腓肠肌湿重比(GW)、腓肠肌纤维横截面积比(GC)、腓肠肌细胞直径比(GD)和腓肠肌细胞凋亡指数(AI)为疗效指标。结果与Ⅰ组相比,Ⅲ组和Ⅳ组的SFI、GW明显增大(P<0.05),Ⅳ组的GC明显增大(P<0.05);与Ⅰ组、Ⅱ组比,Ⅲ组、Ⅳ组的患侧AI明显减小(P<0.05)。结论电针疗效与电针的脉冲波宽有关,100 ms和200 ms的波宽防治肌萎缩的效果明显优于常规电针仪的0.5 ms脉冲。Objective To sift and optimize pulse width for electroacupuncture prevention and treatment of muscular atrophy. Method A model of lower limb muscle atrophy was made in 40 rats. They were randomized into groupsⅠ（no electroacupuncture）, Ⅱ（a pulse width of 0.5 ms and a frequency of 2 Hz）, Ⅲ（a pulse width of 100 ms and a frequency of 2 Hz） and Ⅳ（a pulse width of 200 ms and a frequency of 2 Hz）. Points Zusanli（ST36） and Chengshan（BL57） were given electroacupuncture. Sciatic function index（SFI）, gastrocnemius muscle wet weight ratio（GW）, the cross-sectional area of gastrocnemius muscle fibers（GC）, gastrocnemius muscle cell diameter（GD） and gastrocnemius muscle cell apoptosis index（AI） were used as indicators of therapeutic effect. Result Compared with group Ⅰ, SFI and GW increased significantly in groups Ⅲ and Ⅳ（P〈0.05）. Compared with groups Ⅰ and Ⅱ, AI on the affected side decreased significantly in groups Ⅲ and Ⅳ（P〈0.05）. Conclusion The therapeutic effect of electroacupuncture is related to its pulse width. The pulse widths of 100 ms and 200 ms are significantly more effective than a pulse width of 0.5 ms from a conventional electroacupuncture device in preventing and treating muscular atrophy.

关 键 词：电针 波宽 肌萎缩 坐骨神经功能指数 大鼠 

分 类 号：R203[医药卫生—中医学]