慢加急性乙型肝衰竭患者骨髓源性干细胞自发动员的影响因素  

Influence factors of bone marrow derived stem cell spontaneous mobilization in HBV-related acute on chronic liver failure patients

作　　者：林勇[1] 林春[1] 周锐[1] 黄祖雄[1] 林建辉[1] 林辰青[1] 潘晨[1] 

机构地区：[1]福建省福州市传染病医院肝病科,福州350001

出　　处：《福建医药杂志》2016年第3期60-63,共4页Fujian Medical Journal

基　　金：福州市科技计划社会发展项目(2013-S-125-8)

摘　　要：目的探讨慢加急性乙型肝衰竭患者骨髓源性干细胞自发动员的影响因素。方法入组慢加急性乙型肝衰竭患者66例,收集患者临床资料、血液生化、乙肝病毒学指标及外周血CD34+细胞计数,先后采用双变量回归、多元线性回归分析法对CD34+细胞计数峰值的影响因素进行分析。结果ALT(B=-0.244,P<0.001)、ALT/AST(B=-0.364,P<0.001)、AFP(B=-0.248,P=0.006)、淀粉酶(AMY)(B=0.681,P<0.001)、TG(B=0.578,P<0.001)、胆碱酯酶(CHE)(B=0.16,P=0.04)、国际标准化比值(INR)(B=-0.173,P=0.002)、WBC(B=0.373,P<0.001)对慢加急性乙型肝炎肝衰竭患者骨髓源性干细胞动员的影响具有统计学意义,R2=0.843。结论 ALT、ALT/AST、AFP、INR值与骨髓源性干细胞自发动员呈负相关,AMY、TG、CHE、WBC与骨髓源性干细胞自发动员呈正相关。Objective To investigate the influence factors of bone marrow derived stem cell spontaneous mobilization in HBV-related acute on chronic liver failure （ACLF） patients. Methods A total of 66 HBV related ACLF patients were enrolled. Clinical data, blood biochemistry, HBV virological indicators and peripheral blood CD34 ＋ cell count of patients were collected. Linear regression and multiple linear regression were used to analyze the impact of clinical data, and clinical examination to the peripheral blood CD34＋ ceil count peak. Results The results showed that ALT （B=-0. 244, P〈0. 001）, AI.T/AST （B= -0.364, P〈0.001）, AFP （B= 0.248, P=0.006）, AMY （B=0.681, P〈0.001）, TG （B 0.578, P%0.001）, CHE （B=0.16, P 0.04）, INR （B=-0.173, P=0.002）, WBC （B=0.373, P〈0.001） were statistically significant variable, R^2 =0. 843. Conclusion ALT, ALT/AST, AFP, and INR value are negatively correlated with bone marrow derived stem cells spontaneous mobilization. AMY, TG, CHE, and WBC value are positively correlated with bone marrow derived stem cells spontaneous mobilization.

关 键 词：慢加急性乙型肝衰竭 骨髓源性干细胞 动员 

分 类 号：R575.3[医药卫生—消化系统]