Modification of ubiquitin C-terminal hydrolase L1 by reactive lipid species: role in neural regeneration and diseases of aging  

作　　者：Steven H.Graham 

机构地区：[1]Geriatric Research Educational and Clinical Center, V.A. Pittsburgh Healthcare System

出　　处：《Neural Regeneration Research》2016年第6期908-909,共2页中国神经再生研究（英文版）

基　　金：supported in part by NIH R01 NS37459-15

摘　　要：Role of ubiquitin C-terminal hydrolase L1（UCHL1）in brain function：Ubiquitin is used by a variety of cellular systems to tag proteins for transport to various organelles.There are a number of enzymes in the ubiquitin-proteasome pathway（UPP）that tag abnormally folded proteins with ubiquitin for transport to the proteasome for degradation.Role of ubiquitin C-terminal hydrolase L1（UCHL1）in brain function：Ubiquitin is used by a variety of cellular systems to tag proteins for transport to various organelles.There are a number of enzymes in the ubiquitin-proteasome pathway（UPP）that tag abnormally folded proteins with ubiquitin for transport to the proteasome for degradation.

关 键 词：ubiquitin proteasome regeneration Ubiquitin hydrolase Modification synaptic neuronal lipid enzymes 

分 类 号：R741[医药卫生—神经病学与精神病学]