乳癌改良根治术前纳米炭注射时机的对比研究  

A Comparative Study of the Timing of Carbon Injection before Modified Radical Mastectomy for Breast Cancer

作　　者：赵丽娟[1] 张晓红[1] 张珍[1] 唐卓葳[1] 张靖[1] 龙丽[1] 

机构地区：[1]绵阳市中心医院乳腺外科,四川绵阳621000

出　　处：《四川医学》2016年第6期609-612,共4页Sichuan Medical Journal

摘　　要：目的 探讨不同时间乳晕区皮下注射钠米炭混悬液对乳腺癌腋窝淋巴结的示踪效果。方法 150例乳腺癌患者按入院日期随机分为术前1d给药组、麻醉诱导后给药组、不给药对照组各50例,比较3组患者腋窝淋巴结检获及术后并发症、复发转移情况。结果 术前1天给药组与麻醉诱导后给药组腋窝淋巴结检获均数、黑染率、转移淋巴结检获率、≤2mm淋巴结检获率差异无统计学意义（P〉0.05）,但二者腋窝淋巴结检获均数、转移淋巴结检获率、≤2mm淋巴结检获率均明显高于不给药对照组,差异有统计学意义（P〈0.05）。随访8~26个月三组术后并发症差异无统计学意义（P〉0.05）,均未出现复发转移。结论 与术前1d给药比较,麻醉诱导后于乳晕区皮下注射纳米炭,腋窝淋巴结检获情况相近,同样能够确保病理分期的准确性,又具有无痛的优点,不增加患者术后并发症,值得临床推广。Objective To study the effect of different timing of subcutaneous areolar injection of carbon nanoparticles sus- pension on tracing effect of axillary lymph node in breast cancer. Methods 150 cases of breast cancer patients were randomly di- vided into group of administration 1 day before operation, group of administration after, anesthesia induction, control group with no administration ,50 cases each. The axillary lymph node examination, postoperative complications ,recurrence and metastasis of pa- tients in the three groups were compared. Results Average of seized axillary lymph nodes, black-stained rate, seizure rate of me- tastatic lymph nodes, seizure rate of lymph nodes with diameters equal to or smaller than 2mm （~〈2mm） of administration 1 day before operation group and administration after anesthesia induction group has no statistically significant difference （P 〉 O. 05 ）. but average of seized axillary lymph nodes, seizure rate of metastatic lymph node, seizure rate of lymph nodes with diameters equal to or smaller than 2ram （ 〈~ 2mm）of the two groups is significantly higher than control group, difference being statistically significant （P 〈 0.05 ）. after follow-up Followed up for 8 to 26 months, the three groups had no statistically significant difference in postoperative complications （P 〉 O. 05 ）. There was no recurrence and metastasis. Conclusion Compared to administration 1 day before opera- tion, subcutaneous areolar injection of nano-carbon after anesthesia induction has similar seizure results of axillary lymph nodes and can guarantee the accuracy of pathological staging,with advantages of painless process and no increase in postoperative complica- tions, worthy of clinical application.

关 键 词：纳米炭 乳腺癌 淋巴结 

分 类 号：R737.9[医药卫生—肿瘤]