凝血项目在宫颈癌中的应用价值  

Value of coagulation indexes in cervical cancer treatment

作　　者：田丽贞 曹进 张明娟[2] 陈琦[2] 

机构地区：[1]广东省广州市戒毒管理局医院检验科,510000 [2]中山大学肿瘤防治中心输血科,广东中山510060

出　　处：《国际检验医学杂志》2016年第12期1645-1646,1650,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨宫颈癌患者血液凝血项目与肿瘤治疗效果、预后的关系。方法 297宫颈癌患者进行治疗后随访60个月,每例患者治疗前分别检测活化部分凝血酶原时间(APTT)、纤维蛋白原(Fbg)、凝血酶原时间(PT)、凝血时间(TT)、鳞状细胞癌抗原(SCC-Ag)。结果单因素和Cox多因素分析显示PT危险比(HR)为1.825、肿瘤临床分期、治疗方式与宫颈癌的预后相关。Kaplan-Meier法生存分析显示低PT组(<10.7s)的生存期明显长于高PT组(≥10.7s),差异有统计学意义(P=0.001)。结论术前PT水平是宫颈癌潜在的独立预后指标。Objective To explore the relationship between coagulation indexes and treatment effect,prognosis in patients with cervical cancer.Methods A total of 297 patients with cervical cancer were followed up for 60 months after therapy.The activated partial thromboplastin time（APTT）,Fibrinogen（Fbg）,prothrombin time（PT）,thrombin time（TT）and squamous cell carcinoma antigen（SCCA）of each patient were detected before treatment.Results The analysis of single factor and Cox multivariate factors showed PT level（HR=1.825,P=0.006）,clinical stage of cancer,therapy method were related with the prognosis of cervical cancer.Kaplan-Meier survival analysis showed that the lifetime of the group with low PT level（10.7s）was apparently longer than that of the group with high PT level（≥10.7s）,the difference was statistical significant（P〈0.05）.Conclusion The preoperative PT level is the potential independent index for the prognosis of cervical cancer.

关 键 词：宫颈癌 纤维蛋白原 凝血酶原时间 鳞状细胞癌 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]