参灵固本丸联合化疗治疗晚期非小细胞肺癌临床疗效研究  

Clinical Efficacy Study of Shenling Guben Pill Essence-Reinforcing Pills Combined with Chemotherapy for Advanced NSCLC

作　　者：潘淑云[1] 李秋华[1] 

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《辽宁中医药大学学报》2016年第6期8-10,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省中医药临床学(专)科能力建设项目

摘　　要：目的:研究参灵固本丸联合化疗治疗晚期非小细胞肺癌疗效。方法:将91例住院患者随机分为两组,对照组应用GP方案化疗,治疗组患者应用参灵固本丸5 g,日3次口服。化疗药剂量及用法同对照组,治疗14 d为1疗程。行4周期化疗后观察患者临床症状、体力状况评分、化疗不良反应,判定疗效。并通过生存期(平均生存期、1年生存率)判断远期临床疗效。结果:治疗组(62.2%)有效率优于对照组(41.3%),具有显著性差异(P<0.01);治疗后,治疗组卡氏评分高于对照组(P<0.01),治疗组恶心呕吐、腹泻症状改善,白细胞减少发生率优于对照组(P<0.05),皮疹、血小板减少及肝肾功能损害改善方面,两组间无明显差异(P>0.05)。结论:参灵固本丸联合化疗治疗晚期非小细胞肺癌,可明确减轻化疗毒副作用,缓解不良反应,有效改善患者生存质量,延长生存期,提高远期临床疗效。Objective：To observe the clinical efficacy of Shenling Guben Pill and chemotherapy adianced pill non-small cell lung cancer. Method：Using random parallel control method,91 cases of hospitalized patients were hospitalized sick Chi No. randomized into two groups. Application control group cases GP chemotherapy,the treatment group cases of Shenling Guben Pill 5 g,3 times a day orally. Chemotherapy drug dosage and usage with the control group,treatment 14 d for a course of treatment. At four cycles of chemotherapy in patients with clinical symptoms,physical status score,adverse effects of chemotherapy,to determine efficacy. And through survival（mean survival time,1-year survival）to determine long-term clinical efficacy. Results：There are relatively efficient treatment groups,the treatment group（62.2%）better than the control group（41.3%）,with significant differences（P〈0.01）;after treatment,karnofsky score higher than the control group（P〈0.01）,the treatment group（nausea,vomiting,diarrhea）improvement than the control group（P〈0.05）,rash,neutropenia incidence of thrombocytopenia and liver and kidney dysfunction improvements,no significant difference between the two groups（P〈0.05）. Conclusion：Shenling Guben Pill combined with chemotherapy for non-small cell lung cancer,can clearly reduce the toxic side effects of chemotherapy,alleviate adverse reactions,improve patient quality of life and prolong survival and improve long-term clinical efficacy.

关 键 词：非小细胞肺癌 参灵固本丸 化疗 

分 类 号：R734.2[医药卫生—肿瘤]