老年抑郁症患者认知功能损害与血清皮质醇的关系研究  

Correlation of cognitive impairment in late- life depression patients and cortisol levels

作　　者：钟笑梅[1] 吴章英[1] 王艳华[1] 陈贲[1] 彭琪[1] 陈辛茹[1] 张蔚茹[1] 欧阳聪[1] 胡国艳[1] 林裕龙[1] 陈建平[1] 李含秋[1] 施海姗[1] 宁玉萍[1] 

机构地区：[1]广州医科大学附属脑科医院广州市惠爱医院,广东广州510370

出　　处：《四川精神卫生》2016年第2期123-127,共5页Sichuan Mental Health

基　　金：国家自然科学基金面上项目(81571333);广州市科技计划项目2015年科学研究专项(1563000496);广州市医药卫生科技项目(20141A011044)

摘　　要：目的探讨老年抑郁症(LLD)患者认知功能损害与血清皮质醇水平的关系。方法纳入LLD认知损害患者35例、LLD认知正常患者14例、正常对照组25例,采用汉密尔顿抑郁量表17项版(HAMD-17)和简易智能状态评价量表(MMSE)分别评定抑郁症状和总体认知功能,采用化学发光微粒子免疫法测定血清皮质醇浓度。结果 LLD认知损害患者的血清皮质醇水平高于LLD认知正常者[(11.83±4.70)ug/d Lvs.(8.21±3.64)ug/d L,P<0.01]。LLD发作期伴认知损害者[(11.6±4.6)ug/d L]、LLD恢复期伴认知损害者[(12.4±5.2)ug/d L]血清皮质醇水平均高于LLD恢复期认知正常者[(8.5±3.7)ug/d L]及正常对照组[(8.6±4.3)ug/d L](P均<0.05)。结论伴有认知损害的LLD患者,无论是处于发作期还是恢复期,血清皮质醇水平均升高。皮质醇水平可能是影响LLD患者认知功能的重要因素。Objective To investigate the association between cognitive impairment and levels of serum cortisol in patients withlate - life depression （LLD）. Methods We included 35 LLD patients with cognitive impairment, 14 LLD patients without cognitiveimpairment and 25 normal controls. The Hamilton Depression Scale - 17 item （ HAMD - 17 ） and Mini Mental State Examination（ MMSE） were used to assess the severity of depressive symptoms and the cognitive function, respectively. Serum cortisol levels weremeasured by radioimmunoassay. Results Serum cortisol levels in LLD patients with cognitive impairment were significantly higherthan those in LLD patients without cognitive impairment and normal controls（ All P 〈 0. 01）. LLD patients with cognitive impairment inepisode stage and those in remitted stage showed significantly higher serum cortisol levels than LLD patients without cognitiveimpairment in remitted stage and normal controls （All P 〈0.05）. Conclusion The findings suggest that, in both episode and remittedstages, LLD patients with cognitive impairment show increased serum cortisol levels. High cortisol level might be associated withimpaired cognitive function in LLD patients.

关 键 词：老年抑郁症 认知损害 发作期 恢复期 皮质醇 

分 类 号：R749.4[医药卫生—神经病学与精神病学]