免疫组化在上皮性皮肤肿瘤诊断中的应用进展  

Application of immunohistochemistry in the diagnosis of epithelial skin tumors

作　　者：王小坡[1] 姜祎群[1] 孙建方[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院病理科,南京210042

出　　处：《国际皮肤性病学杂志》2016年第4期226-229,共4页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81272992）;江苏省临床医学科技专项（BL2012003）

摘　　要：上皮性皮肤肿瘤是指来源于皮肤角质形成细胞或皮肤附属器的肿瘤。上皮源性皮肤肿瘤诊断主要依靠形态学特征，在某些诊断困难情况下，免疫组化是一个有价值的辅助诊断指标。包括鉴别肿瘤起源，肿瘤良恶性及原发或者转移性上皮源肿瘤。有时候，需要组合数个抗体来进行明确诊断。在临床实践中对组化结果需要小心解释并结合组织学特征，才能出正确诊断。Epithelial skin tumors are derived from keratinocytes and skin appendages. Their diagnosis mainly depends on morphological features. In some cases difficult to diagnose, immunohistochemistry may be a valuable auxiliary diagnostic tool, which can be used to identify tumor origin and differentiate between benign and malignant neoplasms as well as between primary and metastatic epithelial tumors. Sometimes, several antibodies are needed to be assembled to make a definitive diagnosis. In clinical practice, careful interpretation of immunohistochemical findings and combination of histological features are warranted for a correct diagnosis.

关 键 词：免疫组织化学 肿瘤 基底细胞 毛囊 汗腺肿瘤 皮脂腺肿瘤 

分 类 号：R739.5[医药卫生—肿瘤]