158例青年肺癌患者支气管镜下特征及临床特点分析  

The Bronchoscopic Changes and Clinical Characteristics of 158 cases of Young Patients with Lung Cancer

作　　者：聂华萍[1] 梁伟军[2] 刘胜岗[2] 肖春香[1] 周丽华[2] 

机构地区：[1]湖南工业大学医院,湖南株洲412000 [2]长沙市中心医院,湖南长沙410000

出　　处：《肿瘤药学》2016年第3期212-216,共5页Anti-Tumor Pharmacy

基　　金：湘财社指(2014)30号

摘　　要：目的探讨青年肺癌患者的支气管镜下特征和临床特点。方法对158例青年肺癌患者支气管镜检查结果和临床资料进行回顾性分析。结果 158例青年肺癌患者中,腺癌67例(42.4%),小细胞癌42例(26.6%),鳞癌37例(23.4%),其他12例(7.6%)。所有患者中,无吸烟史者66例,以腺癌为主(80.3%,53/66)。癌变好发于右肺(P<0.05),上叶多于下叶(P<0.05)。支气管镜下表现以直接征象为主(91.8%)。腺癌患者支气管镜下表现以浸润性改变为主(P<0.05),鳞癌和小细胞癌镜下表现均以增生性改变为主(P<0.05);肺不张对应的镜下表现以增生性改变为主(P<0.05),片状阴影对应的镜下表现以浸润性改变为主(P<0.05)。结论在有无吸烟史的青年肺癌患者中,鳞癌、腺癌和小细胞癌的检出率存在差异,不同病变部位、病理类型和影像学表现的青年肺癌镜下表现各有特点,因此支气管镜有助于青年肺癌早期明确诊断。Objective To study the bronchoscopic signs and the clinical characteristics in 158 young patients with lung cancer. Methods The bronchoscopy results and clinical data of 158 young lung cancer patients were analyzed retrospectively. Results Among the 158 young lung cancer patients, the most common histopathology was adenocareinoma （67 cases, 42.4%）, followed by small cell carcinoma （42 cases, 26.6%）, and squamous cell carcinoma （37 cases, 23.4%） and the others （12 cases, 7.6%）. There were 66 patients without smoking history, among which adenocarcinoma （80.3%, 53/66） was the most common pathologic type. The cancer occurrence were more in the right lung for the young patients （P 〈 0.05）, and the upper lobes （P〈0.05）. Among 158 young patients with lung cancer, 91.8% had direct signs. Most of ade had infiltrative changes （P〈0.05）, but most of squamous cell carcinoma and small cell carcinoma had proliferative changes （P〈0.05）. The most common sign of bronchoscopy in patients with atelectasis was proliferative changes （P〈0.05）, but the most common signs of bronchoscopy in patients with patchy shadows were infiltrative changes （P〈0.05）. Conclusions Our study showed there were significantly different detection rate of squamous cell carcinoma, adenocarcinoma and small cell carcinoma in the patients with or without smoking history. There were various characteristics of bronchoscope appearances in different lesion sites, pathological types and imaging changes. Examination with bronchoscopy would be helpful for earlier diagnosis of lung cancer for young patients.

关 键 词：肺癌 支气管镜 青年 临床特点 

分 类 号：R734.2[医药卫生—肿瘤]