Physicochemical Characterization and Solubility Enhancement Studies of Mebendazole Solid Dispersions in Solvent Mixtures  

作　　者：Pefia Maria Angeles Escalera Begofia Torrado Guillermo Natalini Paola 

机构地区：[1]Department of Biomedical Science, Facultad de Farmacia, Universidad de Alcal~, Alcal6 de Henares, Madrid, Spain [2]Planta Piloto de Ingenieria Quimica (Plapiqui-Uns-Conicet), Bahia Blanca, Argentina

出　　处：《Journal of Pharmacy and Pharmacology》2016年第7期351-358,共8页药剂与药理学（英文版）

摘　　要：Abstract： The objective was to obtain solid dispersion to improve the dissolution rate, solubility and oral absorption of MB （mebendazole）, poor water-soluble drugs. The new formulation was characterized by DSC （differential scanning calorimetry）, PXRD （powder X-ray diffraction）, FT-1R （fourier transform infrared spectroscopy） and STEM （scanning transmission electron microscopy） methods. Solid dispersions of MB with polyvinylpyrrolidone K-30 （PVP K30） were prepared by solvent evaporation method. The solubility of MB （original powder） and that of the solid dispersions was measured at 25℃ in ethanol-water. The aqueous solubility of MB was favoured by the presence of the polymer in solvent mixtures. Combination of solid dispersions with co-solvents increased the water solubility of MB in a larger extent that each method separately. Solubility parameter （o） was used to relate to solubility profiles. MB and the solid dispersions show a solubility curve with a single peak at 51 = 30.78 MPav2. Solid state characterizations indicated that the solid dispersion exist an amorphous material entrapped in polymer matrix getting highest improvement in wettability and solubility.

关 键 词：MEBENDAZOLE PVP K30 SOLUBILITY solid dispersion solubility parameter. 

分 类 号：TQ460.6[化学工程—制药化工] TS236.9[轻工技术与工程—粮食、油脂及植物蛋白工程]