沙咪珠利中间体4-硝基邻甲酚中未知杂质的结构确证  

Structural Elucidation of an Unknown Impurity in 4-Nitro-o-cresol, an Intermediate of Acetamizuril

作　　者：张丽芳[1] 朱建德[1] 王米[1] 王霄旸[1] 赵娟[1] 费陈忠[1] 郑文丽[1] 张可煜[1] 王春梅[1] 肖遂[1] 薛飞群[1] 

机构地区：[1]中国农业科学院上海兽医研究所,中国农业科学院兽药安全评价与残留研究重点开放实验室,农业部动物寄生虫学重点开放实验室动物药学研究室,上海200241

出　　处：《中国现代应用药学》2016年第6期683-686,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：国家科技计划项目(2011AA10A214);农业部公益性行业(农业)科研专项(201303038)

摘　　要：目的对沙咪珠利中间体4-硝基邻甲酚中一未知杂质进行结构确证。方法经重氮水解水蒸气蒸馏法制备沙咪珠利中间体4-硝基邻甲酚中一未知杂质,采用高分辨质谱、核磁共振和红外光谱分析等技术对其进行结构确证。结果未知杂质的化学结构被确证为4,6-二硝基邻甲酚。结论中间体4-硝基邻甲酚中一未知杂质的结构确证对沙咪珠利质量控制和生产工艺的改进具有重要作用。OBJECTIVE To identify the structure of an unknown impurity in 4-nitro-o-cresol, an intermediate of acetamizuril. METHODS The impurity was prepared through diazotization hydrolysis and steam distillation. The structure was confirmed by MS, HMR and IR analysis. RESULTS The impurity was identified as 4,6-dinitro-o-cresol. CONCLUSION It is very important for the structure identification of the impurity to control the quality and synthesis process improvement of acetamizuril.

关 键 词：沙咪珠利 4-硝基邻甲酚 杂质 4 6-二硝基邻甲酚 结构确证 

分 类 号：R917.101[医药卫生—药物分析学]