双相Ⅰ型障碍躁狂发作患者高尿酸血症发生率及其影响因素的研究  

Study on the prevalence and relative factors of hyperuricemia in the patients with manic episodes of bipolar Ⅰ disorder

作　　者：陈红梅[1] 田成华[2] 周双桨[1] 王璇[1] 张立刚[1] 陈景旭[1] 王绍礼[1] 

机构地区：[1]北京回龙观医院情感障碍科,100096 [2]北京大学精神卫生研究所

出　　处：《临床精神医学杂志》2016年第3期182-184,共3页Journal of Clinical Psychiatry

基　　金：首都临床特色应用研究(Z131107002213099)

摘　　要：目的:探讨双相I型躁狂发作患者高尿酸血症(HUA)的发生率及其影响因素。方法:检测77例双相I型躁狂发作住院患者(患者组)和77名健康对照者(正常对照组)血清尿酸水平,同时检测体质量、腰臀比、血压及三酰甘油(TG)水平。结果:患者组HUA的发生率28.6%(22例)显著高于正常对照组7.8%(6例)(χ2=11.18,P<0.01)。平均血清尿酸水平患者组(365.19±103.45)μmol/L显著高于正常对照组(301.77±76.04)μmol/L,差异有统计学意义(F=25.70,P<0.01);男性血清尿酸水平高于女性[(381.43±99.02)vs(291.38±70.33)]μmol/L(F=50.08,P<0.01)。相关分析显示,患者组中性别与血清尿酸水平呈负相关(r=-0.56,P<0.01);TG水平与血清尿酸水平呈正相关(r=0.419,P<0.01)。结论:双相I型障碍躁狂发作患者HUA发生率增加并与性别、血清TG水平相关。Objective： To explore the prevalence and relative factors of hyperuricemia（ HUA） in the patients with manic episodes of bipolar I disorder. Method： Seventy-seven inpatients with manic episodes of bipolar disorder（ patient group） and 77 healthy individuals（ normal control group） were enrolled. Serum levels of uric acid,body mass index,waist-hip ratio,blood pressure and three acylglycerin level（ TG） were measured.Results： The prevalence rate of HUA was 28. 6%（ 22 cases） in the patient group and 7. 8%（ 6 cases） in the normal control group. It was significantly higher in patient group than normal control group（ χ2= 11. 18,P〈 0. 01）. The average serum uric acid level of patient group（ 365. 19 ± 103. 45） μmol / L was significantly higher than that of normal control group（ 301. 77 ± 76. 04） μmol / L,the difference was statistically significant（ F =25. 70,P〈 0. 01）. The level of serum uric acid was higher in men than in women [（ 381. 43 ± 99. 02） vs（ 291. 38 ± 70. 33） μmol/L,（ F = 50. 08,P〈 0. 01） ]. Correlation analysis showed gender had negatively correlation（ r =- 0. 56,P〈 0. 01） and TG had positive correlation（ r = 0. 419,P 〈0. 01） with serum levels of uric acid. Conclusion： The prevalence of hyperuricemia in the patients with manic episodes of bipolar I disorder increased,which was associated with gender TG.

关 键 词：双相情感障碍 躁狂发作 高尿酸血症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]