阿托伐他汀联合通心络及脑超声波干预易损斑块治疗缺血性脑血管病用药量分析  

THE DRUGE DOSE ANALYSIS OF COMBINATION THERAPY OF TONGXINLUO AND ATORVASTATIN WITH BRAIN ULTRASOUND ON CAROTID VULNERABLE PLAQUE IN ISCHEMIC CEREBROVASCULAR DISEASE

作　　者：王焕君[1] 李严[1] 吴强[1] 徐成龙[1] 田蕊[1] 李雪艳[1] 

机构地区：[1]河北省沧州市中心医院神经内科,061001

出　　处：《现代电生理学杂志》2016年第2期77-80,86,共5页Journal of Modern Electrophysiology

摘　　要：目的：探讨阿托伐他汀联合通心络及脑超声波干预易损斑块治疗缺血性脑血管病用药剂量。方法：选择缺血性脑血管病患者183例,采用随机数字表法将其分为3组,治疗A组62例,口服通心络4粒,每日3次,阿托伐他汀10 mg,每日1次,同时常规给予脑超声波SUT-800型,超声输出频率800 k HZ,声强0.75~1.25 w/cm2治疗每日一次,每次30min,10 d一个疗程,间隔1周再进行第二个疗程,6个月观察疗效;治疗B组60例,口服通心络4粒,每日3次,阿托伐他汀20 mg,每日1次,另加脑超声波治疗同治疗A组,6个月后观察疗效;对照组61例：仅给予口服普通降脂药心脑清及脑超声波治疗。观察3组患者治疗前后血脂变化及脂肪斑块情况。结果：与治疗前比较,治疗A组和B组,血清TC、TG、LDL-C浓度下降,HDL-C浓度升高,颈动脉IMT明显变小或消失,易损斑块减少,稳定斑块明显增加,斑块长径及厚度积分明显变小（P〈0.05）,对照组治疗前后血脂水平及板块性质、数目差异无统计学意义;治疗后,与对照组比较,治疗A组和B组血脂水平下降,斑块长泾及厚度积分变小（P〈0.05）;与治疗A组比较,B组血脂水平及斑块情况差异无统计学意义。结论：阿托伐他汀联合通心络、脑超声波治疗能明显降低血脂水平,干预颈动脉脂肪斑块疗效明显,而且可以减少阿托伐他汀的用药剂量。Objective： To explore druge dose of combination therapy of tongxinluo and atorvastatin with brain ultrasound on carotid vulnerable plaque in ischemic cerebrovascular disease. Methods： One hundred and eight-three patients with ischemic cerebrovascular disease were randomly divided into 3 groups, the treatments of tongxinluo and atorvastatin with rain ultrasound were as treatment group A（n=62）： oral administration of tongxinluo for 3 times a day, and 4 capsules in each time; atorvastatin one time a day, and 10 mg in each time; simultaneously, routine brain ultrasound treatment SUT-800 type was given once a day, the ultrasound output frequency is 800 khz, the intensity is 0.75-1.25w/cm, the duration is 30 minutes per time. 10 days of treatment were set as one course of therapy, and the second course took place every other week; efficacy was investigated after 6 months of treatment. The treatment group B（n=60）： atorvastatin 20 mg in each time, other exactly same as that of group A. The control group（n=61）： Only give oral common lipid-lowering cardio-cerebral Xinnaoqing without atorvastatin and cerebral ultrasonic therapy. The blood lipid and fatty plaques were observed before and after treatment. Results： Compared with before treatment, group A and group B, serum TC, TG, LDL-C concentration droped, HDL-C increased, carotid artery IMT significantly shrinked or disappeared, the vulnerable plaques reduced, stable plaque increased significantly, and plaque thickness and length to diameter decreased significantly（P 〈0.05）, there was no statistically significant in blood lipid levels and the nature and numbers of the plaque before and after the treatment in control group; Compared with control group, group A and group B lipid levels droped, plaque length diameter and thickness decreased（P〈 0.05）; Compared with group A, there was no statistically significant in lipid levels and plaques state in group B. Conclusion： The therapy with atorvastatin combined tongxinluo and cerebral ultrasoni

关 键 词：通心络 阿托伐他汀 脑超声波 缺血性脑血管病 

分 类 号：R743[医药卫生—神经病学与精神病学]