SIRT3基因在器官缺血-再灌注损伤中的作用  

Role of Gene SIRT3in Ischemia-Reperfusion Injury

作　　者：张秋艳[1] 薛成彪 叶少军[1] 王彦峰[1] 周敏[1] 王勇[1] 叶啟发[1,2] 

机构地区：[1]武汉大学中南医院/武汉大学肝胆疾病研究院/武汉大学移植医学中心/移植医学技术湖北省重点实验室,湖北武汉430071 [2]中南大学湘雅三医院/卫生部移植医学工程技术研究中心,湖南长沙410013

出　　处：《武汉大学学报（医学版）》2016年第4期592-594,共3页Medical Journal of Wuhan University

摘　　要：器官移植是挽救各器官终末期疾病的先进医学科学技术,缺血-再灌注(IR)损伤在器官移植过程中不可避免,缺血时细胞能量来源减少,再灌注时发生氧化应激,最终激活一系列通路,导致细胞死亡,影响供者器官的质量及术后移植肝功能的恢复。SIRT3是Sirtuin蛋白家族的成员,主要位于线粒体基质,在细胞能量代谢以及氧化应激过程中有着重要的调节作用。本文就SIRT3基因在器官IR损伤中的作用作一综述。Organ transplantation is the mature clinical approach for treatment of differeat kinds of organ failure.And ischemia-reperfusion（IR）injury is inevitable in the transplanting process,the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury,which may affect the quality of donor organs and extend the postoperative recovery of recipients.SIRT3 is a member of the Sirtuins,mainly located in the mitochondrial matrix,which can regulate cellular energy metabolism and oxidative stress related pathways.This review is going to describe the role that SIRT3 plays during ischemia-reperfusion injury.

关 键 词：器官移植 缺血-再灌注损伤 SIRT3 线粒体 

分 类 号：R364.4[医药卫生—病理学]