不同剂量甘露醇治疗老年急性大面积脑梗塞的效果  

Different doses of mannitol for elderly patients with acute large area cerebral infarction

作　　者：邹达良 黎罗明[1] 冯欣[1] 李华文[1] 周映彤[1] 

机构地区：[1]中山市陈星海医院神经内科,528415

出　　处：《国际医药卫生导报》2016年第14期2119-2121,共3页International Medicine and Health Guidance News

摘　　要：目的 探讨不同剂量甘露醇治疗老年急性大面积脑梗塞的效果.方法 以本院76例老年急性大面积脑梗塞患者为研究对象,将其随机分成2组,A组（38例）在吸氧、抗凝血、扩血管、脑保护剂基础上使用小剂量甘露醇治疗,B组（38例）使用大剂量甘露醇治疗,比较2组治疗效果.结果 2组治疗过程中无死亡病例;A组治疗后ESS评分（61.8±14.2）分,总有效率57.9％,B组治疗后ESS评分（62.4±14.6）分,总有效率60.5％,组间比较差异无统计学意义（P＞0.05）;A组肝功异常、肾功异常、心衰和电解质紊乱发生率13.2％、15.8％、2.6％和23.7％,B组肝功异常、肾功异常、心衰和电解质紊乱发生率39.5％、44.7％、18.4％和55.3％,A组并不良反应发生率明显少于B组（P＜0.05）.结论 小剂量甘露醇治疗老年急性大面积梗塞的疗效与大剂量相当,降低了不良反应发生率,值得进一步应用.Objective To investigate the effect of different doses of mannitol for elderly patients with acute massive cerebral infarction.Methods 76 elderly patients with acute large area cerebral infarction were included and randomly divided into two groups.Group A （n=38） were treated with a small dose of mannitol and group B （38 cases） a large dose.The clinical efficacies were compared between these two groups.Results No one ended in death in both groups.After the treatment,the ESS score and total effective rate were （61.8±14.2）and 57.9% in group A and were （62.4 ±14.6） and 60.5% in group B,with no statistical differences（P〉0.05）.The incidences of liver abnormality,renal abnormality,heart failure,and electrolyte disorder were 13.2%,15.8%,2.6%,and 23.7% in group A and were 39.5%,44.7%,18.4%,and 55.3% in group B （P〈0.05）.Conclusion A small dose of mannitol in the treatment of elderly patients with acute large area cerebral infarction is as effective as a large dose and can decrease the incidence of adverse reactions,so it is worth being applied.

关 键 词：甘露醇 老年急性大面积脑梗塞 治疗效果 不良反应 

分 类 号：R743.33[医药卫生—神经病学与精神病学]