亚洲人群NQO1 C609T基因多态性与胃癌易感性的Meta分析  

A meta-analysis of association of NQO1 C609T gene polymorphism with gastric cancer susceptibility in Asian population

作　　者：胡星[1] 邬四明[1] 王昕[1] 黄智明[1] 

机构地区：[1]通城县人民医院普外科,湖北咸宁437400

出　　处：《中国热带医学》2016年第6期608-611,共4页China Tropical Medicine

摘　　要：目的探讨亚洲人群NQO1 C609T基因多态性与胃癌易感性关系。方法计算机检索数据库,收集有关亚洲人群NQO1 C609T基因多态性与胃癌病易感性关系病例对照研究,提取纳入文献的相关数据进行Meta分析,以病例组与对照组NQO1 C609T各种基因模型的比值比(OR)为效应指标,Egger's检验和Bgger's检验偏倚。结果共7篇研究符合纳入标准,累计病例数1 584例,对照组2 263例。meta分析表明NQO1 C609T基因多态性与胃癌病易感性有明显关联性。结论亚洲人群NQO1 C609T基因多态性与胃癌病易感性明显关联性[CC vs.TT;OR=1.19,95%CI:0.99,1.44,P=0.070;TC vs.TT:OR=1.10,95%CI:0.97,1.25,P=0.137;CC/TC vs.TT:OR=1.10,95%CI:0.98,1.22,P=0.100;CC vs.TC/TT:OR=1.19,95%CI:0.89,1.59,P=0.233]。Objective To explore the association between NQO1 C609 T gene polymorphism and gastric cancersusceptibility in Asian population. Methods Data bases were comprehensively searched to retrieve all related data inassociation between NQO1 C609 T polymorphism and gastric cancer susceptibility in Asian population. Meta- analysis wasapplied to study the related data from literatures with odds ratio（OR）for NQO1 C609 T various genetic model as effect index inthe case group and control group. Egger＇s and Bgger＇s inspections were used to test bias. Results Seven original studiesfulfilled the inclusion criteria with a total of 1 584 patients and 2 263 controls entered into study dataset. Meta- analysesshowed significant associations between NQO1 C609 T polymorphism and gastric cancer susceptibility in Asian population [CCvs. TT：OR=1.19,95% CI：0.99-1.44,P=0.070;TC vs. TT：OR=1.10,95% CI： 0.97-1.25,P=0.137;CC/TC vs. TT：OR=1.10,95% CI：0.98- 1.22,P=0.100;CC vs. TC/TT：OR=1.19,95% CI：0.89-1.59,P=0.233]. Conclusion Meta-analysis stronglysuggests that there is significant association between NQO1 C609 T polymorphism and gastric cancer susceptibility in Asianpopulation.

关 键 词：依赖还原型辅酶Ⅰ醌氧化还原酶1 基因多态性 胃癌 易感性 META分析 

分 类 号：R735.2[医药卫生—肿瘤]