Rhein: a novel potential antitumor drug  

大黄酸:一种新型潜在抗肿瘤药物（英文）

作　　者：俞璐 姚国栋[2] 马卫成 

机构地区：[1]宁波市泌尿肾病医院临床药学,浙江宁波315400 [2]沈阳药科大学中日医药研究所,辽宁沈阳110016

出　　处：《Journal of Chinese Pharmaceutical Sciences》2016年第5期321-328,共8页中国药学（英文版）

摘　　要：Rhein （4,5-dihydroxyanthraquinone-2-carboxylic acid） is an anthraquinone compound enriched in the rhizome of rhubarb （Rheum palmatum or Rheum tanguticum Maxim）, a traditional Chinese medicine herb. Natural product compounds are a source of novel therapeutic agents. Rhein has been initially identified as an anti-inflammatory and anti-oxidant agent. Recent studies indicate that rhein may also have an antitumor effect. However, the molecular mechanisms are still unclear. This review aims to summarize the research of rhein to better understand the anti-tumor activities by targeting cell cycle arrest, apoptosis, invasion, and metastasis of cancer cells. Meanwhile, we also intend to give an overview of the mechanisms identified so far. The breakthrough findings may shed light on using rhein as a targeted-cancer therapy.大黄酸,化学结构式为1,8-二羟基-3-羧基蒽醌,是富含于大黄根茎中的一种蒽醌类化合物,已经被证实具有抗炎与抗氧化的作用。最近研究发现,大黄酸可能还具有抗肿瘤的功能,然而其抗肿瘤的分子机制目前还未知。该综述主要概括分析了大黄酸研究的相关结果,以此推出大黄酸通过细胞周期阻滞、诱导细胞凋亡以及控制转移而发挥抗肿瘤作用。

关 键 词：RHEIN Cancer cells APOPTOSIS Cell cycle arrest 

分 类 号：R285[医药卫生—中药学]