辛伐他汀对食管癌细胞放疗敏感性的影响  

Simvastatin enhances the radiosensitivity of esophageal squamous cell carcinoma

作　　者：金迎迎[1] 卫阳[2] 王力[1] 何赟[1] 贾辉[1] 马红兵[1] 孙晓力[3] 

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004 [2]西安交通大学第二附属医院科研中心实验室,陕西西安710004 [3]西安交通大学第二附属医院普外科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2016年第4期565-568,581,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的观察辛伐他汀对食管癌细胞放疗敏感性的影响。方法应用间断照射的方法诱导食管癌细胞EC9706的放射抗拒细胞R-resistant;Cell Counting Kit-8检测辛伐他汀联合放疗对食管癌细胞EC9706及其放射抗拒细胞R-resistant增殖的影响;集落形成实验检测辛伐他汀对食管癌细胞EC9706及其放射抗拒细胞R-resistant的放疗敏感性的影响。结果成功诱导出食管癌细胞EC9706的放射抗拒细胞R-resistant,Cell Counting Kit-8实验及集落形成实验结果都显示辛伐他汀可以增强食管癌细胞EC9706及其放射抗拒细胞R-resistant对放疗的敏感性。结论辛伐他汀可以增强食管癌细胞的放疗敏感性。Objective To study the effect of simvastatin on the radiosensitivity of esophageal squamous cell carcinoma .Methods Interrupted radiation was used to induce the radioresistance EC 9706 ,named R‐resistant cell . The effect of simvastatin on the proliferation and radiosensitivity of EC 9706 and R‐resistant cells were examined by Cell Counting Kit‐8 assay and colony formation assay ,respectively .Results The radioresistance EC9706 ,named R‐resistant ,was induced successfully .The results of Counting Kit‐8 assay and colony formation assay indicated that simvastatin could sensitize EC9706 and the radioresistance of R‐resistant to irradiation .Conclusion Simvastatin can sensitize esophageal squamous cell carcinoma to irradiation .

关 键 词：辛伐他汀 食管癌 放疗抗拒 增敏 

分 类 号：R735.1[医药卫生—肿瘤]