Slit-Robo信号通路在心血管发育中的作用  

Slit-Robo signal pathway in cardiovascular development

作　　者：张冰[1] 傅怡[1] 

机构地区：[1]上海交通大学系统生物医学研究院,上海200240

出　　处：《上海大学学报（自然科学版）》2016年第3期331-335,共5页Journal of Shanghai University:Natural Science Edition

基　　金：国家自然科学基金重大研究计划资助项目(91539109);国家自然科学青年基金资助项目(11302129)

摘　　要：近期研究表明,Slit-Robo信号通路对心血管系统的发育和再生发挥了重要功能.Slit3作为促血管新生因子,能够与其受体Robo4结合,通过Rho GTPase信号通路调控多个生理和病理过程中的血管新生.Slit3-Robo4信号通路的激活能够促进工程组织中血管网络的形成.硫酸乙酰肝素通过Slit3-Robo4通路能够调节膈肌发育及其血管新生.Slit-Robo信号通路还参与调控心脏系统静脉回流和心包膜的发育.Slit3的缺失会导致小鼠发育过程中的肾脏缺失和输尿管发育不全.因此,进一步研究Slit3-Robo4信号通路对于阐释心血管系统发育和疾病的病因具有重要理论意义,有望为心血管疾病的预防和治疗提供有力的药物作用靶点,促进有效药物的开发.Slit-Robo pathway has recently been shown to be vital in cardiovascular devel- opment and regeneration. Slit3, a proangiogenic factor, regulates angiogenesis and organ formation in embryonic development by binding to its receptor Robo4. Activation of Slit3- Robo4 promotes formation of vascular network in engineered tissues. Heparan sulfate regulates the development of blood vessel and diaphragm through modulating the Slit3- Robo4 signal pathway. Moreover, the Slit-Robo signal pathway plays an essential role in developing cardiac systematic venous return and pericardium. Deficiency of Slit3 leads to developmental defect of other organs such as kidney and ureter. Therefore, further understanding of the Slit3-Robo4 signal pathway in the future may provide a theoretical foundation and therapeutic targets for prevention and therapy of cardiovascular and related diseases.

关 键 词：Slit3-Robo4信号通路 血管新生 发育 

分 类 号：R363[医药卫生—病理学]