紫杉醇脂质体加替吉奥联合精确放疗治疗中晚期贲门癌疗效观察  

Clinical observation of paclitaxel liposome combined with S-1 combined with precise radiotherapy in treatment of advanced gastric cardia

作　　者：李红[1] 吴兵[1] 

机构地区：[1]山东省威海市文登中心医院肿瘤科,264400

出　　处：《中国老年保健医学》2016年第3期38-40,共3页Chinese Journal of Geriatric Care

摘　　要：目的观察紫杉醇脂质体加替吉奥联合精确放疗治疗晚期贲门癌患者的近期疗效和不良反应。方法全组82例患者随机分为两组。治疗组:紫杉醇脂质体80mg/m^2静滴3小时,d1,d8;替吉奥60mg,2次/日,d1~14天;化疗第一天开始放疗。21天为1周期,连用2个周期,放疗采用三维精确放疗。对照组:单纯采用三维精确放疗。结果治疗组总有效率明显高于对照组(88.09%>62.50%P<0.01),主要不良反应为骨髓抑制,治疗组较对照组略有加重。结论紫杉醇脂质体加替吉奥联合精确放疗治疗晚期贲门癌患者疗效较好,不良反应可耐受,值得临床推广应用。Objectives To observe the efficacy and adverse reactions of paclitaxel liposome combined with S-1 with precise ra- diotherapy for patients with advanced gastric cardia cancer. Methods 82 patients were randomly divided into two groups. The treat- ment group： paclitaxel liposome 80mg/m2 ivdrip 3h dl ,8; S-160mg bid po dl-14; the first day of radiotherapy chemotherapy. 21 days for 1 cycles,2 cycles,radiotherapy using three-dimensional accurate radiotherapy. Control group： simple use of three-dimension- al accurate radiotherapy. Results The total effective rate of the treatment group was significantly higher than that of the control group （P 〈 0. 01 88.09% 〉 62. 50 ） ,the main adverse reactions were bone marrow suppression, and the treatment group was signifi- cantly higher than the control group. Conclusions Paclitaxel liposome combined with S-1 with precision radiotherapy in the treat- ment of advanced cardia cancer patients better, adverse reactions can be tolerated,it is worthy of clinical application.

关 键 词：贲门癌 晚期 精确放疗 紫杉醇脂质体 替吉奥 

分 类 号：R735.2[医药卫生—肿瘤]