转化生长因子-β超家族成员在牙本质发生发育中的作用  

Roles of transforming growth factor-β superfamily in dentinogenesis

作　　者：陈尽欢[1] 孙建勋[1] 陈新梅[1] 

机构地区：[1]口腔疾病研究国家重点实验室华西口腔医院牙体牙髓病科(四川大学),成都610041

出　　处：《国际口腔医学杂志》2016年第4期477-481,共5页International Journal of Stomatology

基　　金：国家自然科学基金(81300847)~~

摘　　要：转化生长因子(TGF)超家族是一类在细胞分化、增殖和程序性死亡中参与调控的重要生长因子,具有相似的蛋白质高级结构,其中包括TGF-β、骨形态发生蛋白(BMP)和生长分化因子(GDF)、激活蛋白(ACT)和抑制蛋白等,它们通过其相应的受体介导转导信号。牙本质是牙体组织结构中的主要支持部分,由成牙本质细胞分泌的基质矿化而成。当成牙本质细胞分泌胞外基质并矿化时,TGF-β参与基质形成和矿化的调控,调控成牙本质细胞排列;BMP参与调节多种转录因子的表达,介导牙发生发育中上皮间质的相互作用;GDF在牙发生发育时调控牙周组织形成;ACT则调节细胞增殖分化,参与免疫应答,修复损伤等。本文就TGF-β超家族成员在牙本质发育中的作用等研究进展作一综述。Transforming growth factor（TGF）-β superfamily is a group of essential growth factors involved in the regulation of cell proliferation, differentiation, and apoptosis. TGF-β, bone morphogenetic protein（BMP）, growth differentiation factor（GDF）, activin（ACT）, inhibin and so on, share a set of similar spatial structures of proteins. Dentin, as the important supportive part of tooth structure, is formed with mineralized matrix, which secreted by odontoblasts. During dentin formation, TGF-β1 participates in the regulation of matrix formation, mineralization, and the odontoblasts arrangement; BMP involved in the adjustment of many transcription factors’ expression and mediated epithelialmesenchymal interaction in dentification; while GDF play roles in periodontal development and ACT regulates cell metabolism, inmmune response, damage repairment and so on. This article reviewed the advances on the roles of TGF-β superfamily in dentinogenesis.

关 键 词：转化生长因子 牙本质 牙发生发育 

分 类 号：R781[医药卫生—口腔医学]