血清肝细胞生长因子在烟雾病患者的表达及意义  

Expression and Significance of Serum Hepatocyte Growth Factor in Patients with Moyamoya Disease

作　　者：魏丹[1] 杨玉峰[1] 侯玉芹[1] 

机构地区：[1]安阳地区医院神经内科,河南安阳455000

出　　处：《中外医疗》2016年第11期61-63,共3页China & Foreign Medical Treatment

摘　　要：目的探索血清肝细胞生长因子(HGF)在烟雾病患者的表达及意义。方法随机选取该院神经内科2013年8月—2015年6月收治的22例烟雾病患者和同期体检中心30例健康体检者作为研究对象,分为烟雾病组和健康对照组,应用酶联免疫吸附法(ELISA法)测定烟雾病组和健康对照组空腹血清HGF的表达。结果烟雾病组患者血清HGF浓度为(1108.320±290.811)pg/m L,健康对照组血清HGF浓度为(720.496±112.579)pg/m L,烟雾病组HGF浓度显著高于健康对照组,两组比较差异有统计学意义(t=3.715,P<0.05)。结论 HGF可能作为一种促血管生成因子在烟雾病的病程中发挥重要作用。Objective To explore the expression and significance of serum hepatocyte growth factor in patients with？moy- amoya disease. Methods 22 cases of patients with moyamoya disease？admitted and treated in the department of neurology of our hospital from August 2013 to June 2015 were selected as the？moyamoya disease group, the 30 cases of healthy exam- ined persons in our hospital at the same period were selected as the healthy control group, and the expression of the？fasting serum I-IGF of the two groups was measured by the enzyme-linked immunosorbent assay method. Results The concentration of serum HGF in the moyamoya disease group was obviously higher than that in the healthy control group [（1108.320± 290.811） pg/mL vs （720.496±112.579） pg/mL）], and the difference had statistical significance by comparison（t=3.715,P〈0.05）. Conclusion HGF may play an important role in the process of moyamoya disease as a kind of proangiogenic factors.

关 键 词：肝细胞生长因子 烟雾病 

分 类 号：R743.4[医药卫生—神经病学与精神病学]