3,5-二溴-2-氨基吡嗪的合成研究  

Synthesis of 3,5- dibromopyrazin- 2- amine

作　　者：姜卫东[1,2] 王瑜[1] 刘明星[1] 

机构地区：[1]湖北工业大学生物工程与食品学院,协同创新中心,湖北武汉430068 [2]湖北振华化学股份有限公司,湖北黄石435001

出　　处：《广州化工》2016年第12期93-94,126,共3页GuangZhou Chemical Industry

摘　　要：制备3,5-二溴-2-氨基吡嗪,并优化工艺。以2-氰基吡嗪为原料,经水解、重排一锅法得到2-氨基吡嗪,再用N-溴代丁二酰亚胺(NBS)溴化得3,5-二溴-2-氨基吡嗪。目标产物经1H-NMR和MS确认,与标准图谱相符;改进后的制备工艺所用原料和试剂工业上易得,价格低廉,操作简单,反应温和,产品纯度高,环境污染小,总收率达到62%,含量大于99%(HPLC),可适合规模化生产。The 3,5- dibromopyrazin- 2- amine was prepared and preparation parameters were optimized. The 2-Amino pyrazine was prepared by one- pot method via rearrangement and hydrolysis reaction using 2- cyanopyrazine. 3,5- dibromopyrazin- 2- amine was synthesized using NBS as a bromating agent. The 3,5- dibromopyrazin- 2- amine was identified by1H- NMR and MS. Meanwhile,the above preparation parameters were optimized. The total yield was 62%and the purity was more than 99%（ HPLC）. This method has some advantages of cheap materials,simple operation,lower environment pollution,a gentle reaction conditions and higher application value for the industrial production.

关 键 词：2-氰基吡嗪 重排 NBS 3 5-二溴-2-氨基吡嗪 

分 类 号：R914.5[医药卫生—药物化学]