在OHSS高危患者中卵裂期胚胎移植与囊胚移植的临床结局分析  

Clinical outcomes of cleavage-stage embryo transfer versus blastocyst transfer in patients with high-risk of hyperstimulation syndrome

作　　者：倪晓蓓 王珊珊[1] 张宁媛[1] 孙海翔[1] 

机构地区：[1]南京大学医学院附属鼓楼医院生殖医学中心,南京210008

出　　处：《生殖医学杂志》2016年第7期610-613,共4页Journal of Reproductive Medicine

摘　　要：目的比较卵裂期胚胎移植与囊胚移植在卵巢过度刺激综合征(OHSS)高危患者首次冷冻复苏周期中应用的临床结局。方法回顾性分析2014年1月至2015年6月在本中心进行体外受精的首次冷冻复苏周期OHSS高危患者,均有卵裂期胚胎冷冻和囊胚冷冻,总例数为232例,将卵裂期胚胎移植组设为A组共84例,囊胚移植组设为B组共148例;分析两组患者年龄、体重指数、基础激素水平、内膜厚度及临床结局。结果 A组患者84例,行卵裂期胚胎移植,临床妊娠61例,临床妊娠率72.62%;B组患者148例,临床妊娠125例,临床妊娠率84.46%,临床妊娠率有统计学差异(P<0.05)。两组患者的年龄、基础激素水平、体重指数、内膜厚度均无统计学意义(P>0.05)。结论在体外受精-胚胎移植中,OHSS高危患者可以优先考虑囊胚移植。Objective： To compare the clinical outcome of cleavage-stage embryo transfer and blastocyst transfer in the first frozen-thawed cycle in the patients with high-risk of ovarian hyperstimulation syndrome （OHSS）. Methods： The data of 232 patients with high-risk of OHSS in the first frozen-thawed IVF cycle in our reproductive center from January 2014 to June 2015 were retrospectively analyzed The patients were divided into two groups： the patient with cleavage-stage embryo transfer in group A （n = 84） and the patients with blastocyst transfer in group B （n= 148）. The patients＇ age, body mass index （BMI）, baseline hormone levels,endometrial thickness and clinical outcomes were compared between the two groups. Results： The clinical pregnancy rate in group A was significantly lower than that in group B [72.62% （61/84） vs. 84. 46% （125/148）] （P〈0.05）. There were no significant differences in age,BMI,baseline hormone levels,endometrial thickness between the two groups （P〉0.05）. Conclusions： The blastocyst transfer should be considered to adopt preferentially for the patients with high-risk of OHSS.

关 键 词：OHSS 卵裂期胚胎 囊胚 临床妊娠率 

分 类 号：R[医药卫生]